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  1. Case report

    A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~

    Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

    Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui and Kenichi Tsujita

    Thrombosis Journal 2017 15:8

    Published on: 14 March 2017

  2. Research

    The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor

    An increasing number of patients are treated with direct-acting oral anticoagulants (DOACs), but the optimal way to reverse the anticoagulant effect is not known. Specific antidotes are not available and proth...

    Nina Haagenrud Schultz, Hoa Thi Tuyet Tran, Stine Bjørnsen, Carola Elisabeth Henriksson, Per Morten Sandset and Pål Andre Holme

    Thrombosis Journal 2017 15:6

    Published on: 20 February 2017

  3. Case report

    Successful treatment of deep vein thrombosis caused by iliac vein compression syndrome with a single-dose direct oral anti-coagulant

    Although vein stenting is popular for treatment for venous thromboembolism due to mechanical compression, some cases are forced to avoid inserting align agents because of immunodeficiency.

    Naoya Nakashima, Daisuke Sueta, Yusuke Kanemaru, Seiji Takashio, Eiichiro Yamamoto, Shinsuke Hanatani, Hisanori Kanazawa, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto and Kenichi Tsujita

    Thrombosis Journal 2017 15:4

    Published on: 1 February 2017

  4. Research

    Pro-coagulant activity during exercise testing in patients with coronary artery disease

    Strenuous exercise may trigger myocardial infarction through increased pro-coagulant activity. We aimed to investigate whether patients referred for exercise testing, who were found to have angiographically ve...

    Joanna Cwikiel, Ingebjorg Seljeflot, Eivind Berge, Harald Arnesen, Kristian Wachtell, Hilde Ulsaker and Arnljot Flaa

    Thrombosis Journal 2017 15:3

    Published on: 19 January 2017

  5. Research

    A survey of thrombosis experts evaluating practices and opinions regarding venous thromboprophylaxis in patients post major abdominal surgery

    Patients undergoing major abdominal surgery are at high risk for developing venous thromboembolism in the post-operative period. Current evidence-based guidelines recommend routine pharmacological venous throm...

    Bader Al Rawahi, Grégoire Le Gal, Rebecca Auer and Marc Carrier

    Thrombosis Journal 2017 15:2

    Published on: 13 January 2017

  6. Research

    The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese

    Genome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (ADTRP) gene is associated with coronary ar...

    Xuling Chang, Hui-Lin Chin, Swee-Chye Quek, Daniel Y. T. Goh, Rajkumar Dorajoo, Yechiel Friedlander and Chew-Kiat Heng

    Thrombosis Journal 2017 15:1

    Published on: 7 January 2017

  7. Research

    Edoxaban versus enoxaparin for the prevention of venous thromboembolism after total knee or hip arthroplasty: pooled analysis of coagulation biomarkers and primary efficacy and safety endpoints from two phase 3 trials

    The objective of this analysis was to assess the effects of edoxaban compared with enoxaparin on key coagulation biomarkers and present pooled primary efficacy and safety results from phase 3 STARS E-3 and STA...

    Yohko Kawai, Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe and Shintaro Tachibana

    Thrombosis Journal 2016 14:48

    Published on: 1 December 2016

  8. Research

    CD163 macrophage and erythrocyte contents in aspirated deep vein thrombus are associated with the time after onset: a pilot study

    Thrombolytic therapy is effective in selected patients with deep vein thrombosis (DVT). Therefore, identification of a marker that reflects the age of thrombus is of particular concern. This pilot study aimed ...

    Eiji Furukoji, Toshihiro Gi, Atsushi Yamashita, Sayaka Moriguchi-Goto, Mio Kojima, Chihiro Sugita, Tatefumi Sakae, Yuichiro Sato, Toshinori Hirai and Yujiro Asada

    Thrombosis Journal 2016 14:46

    Published on: 22 November 2016

  9. Research

    Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells

    Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...

    Valentina Scalise, Cristina Balia, Silvana Cianchetti, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Maria Franzini, Alessandro Corti, Aldo Paolicchi, Alessandro Celi and Roberto Pedrinelli

    Thrombosis Journal 2016 14:45

    Published on: 4 November 2016

  10. Research

    Low-molecular-weight-heparin can benefit women with recurrent pregnancy loss and sole protein S deficiency: a historical control cohort study from Taiwan

    Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...

    Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin and Ming Chen

    Thrombosis Journal 2016 14:44

    Published on: 28 October 2016

  11. Review

    Extravascular FIX and coagulation

    This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...

    Darrel W. Stafford

    Thrombosis Journal 2016 14(Suppl 1):35

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  12. Review

    Thrombophilia in East Asian countries: are there any genetic differences in these countries?

    In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...

    Toshiyuki Miyata, Keiko Maruyama, Fumiaki Banno and Reiko Neki

    Thrombosis Journal 2016 14(Suppl 1):25

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  13. Review

    Individualized prophylaxis for optimizing hemophilia care: can we apply this to both developed and developing nations?

    Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...

    Man-Chiu Poon and Adrienne Lee

    Thrombosis Journal 2016 14(Suppl 1):32

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  14. Research

    Characteristics of Taiwanese patients of PNH in the international PNH registry

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...

    Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin and Ming-Ching Shen

    Thrombosis Journal 2016 14(Suppl 1):39

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  15. Review

    Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome

    Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...

    Yu-Min Shen

    Thrombosis Journal 2016 14(Suppl 1):19

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  16. Research

    De novo mutation and somatic mosaicism of gene mutation in type 2A, 2B and 2M VWD

    Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

    Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh

    Thrombosis Journal 2016 14(Suppl 1):36

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  17. Review

    MicroRNA in atherothromobosis: is it useful as a disease marker?

    Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

    Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte

    Thrombosis Journal 2016 14(Suppl 1):21

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

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