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  1. Research

    De novo mutation and somatic mosaicism of gene mutation in type 2A, 2B and 2M VWD

    Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

    Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh

    Thrombosis Journal 2016 14(Suppl 1):36

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  2. Review

    MicroRNA in atherothromobosis: is it useful as a disease marker?

    Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

    Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte

    Thrombosis Journal 2016 14(Suppl 1):21

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  3. Review

    Preimplantation genetic diagnosis of hemophilia A

    Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...

    Ming Chen, Shun-Ping Chang, Gwo-Chin Ma, Wen-Hsian Lin, Hsin-Fu Chen, Shee-Uan Chen, Horng-Der Tsai, Feng-Po Tsai and Ming-Ching Shen

    Thrombosis Journal 2016 14(Suppl 1):33

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  4. Review

    Aspects of prophylactic treatment of hemophilia

    Retrospective and prospective studies unambiguously show that prophylactic treatment of severe hemophilia A or B should be started as primary prophylaxis at 1–2 years’ of age and ideally before the first joint...

    Rolf Ljung

    Thrombosis Journal 2016 14(Suppl 1):30

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  5. Review

    Causes of venous thrombosis

    Venous thrombosis which mainly manifests as deep vein thrombosis of the leg or pulmonary embolism occurs in 1 per 1000 per year. It occurs due to interacting genetic, environmental and behavioral risk factors....

    F. R. Rosendaal

    Thrombosis Journal 2016 14(Suppl 1):24

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  6. Review

    Cancer-associated thrombosis in Asia

    Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associat...

    Pantep Angchaisuksiri

    Thrombosis Journal 2016 14(Suppl 1):26

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  7. Review

    Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome

    The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...

    Fatima El-Assaad, Steven A. Krilis and Bill Giannakopoulos

    Thrombosis Journal 2016 14(Suppl 1):20

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  8. Review

    Current animal models of hemophilia: the state of the art

    Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...

    Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu and Shu-Wha Lin

    Thrombosis Journal 2016 14(Suppl 1):22

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  9. Review

    Anti-thrombotic agents derived from snake venom proteins

    Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...

    Tur-Fu Huang, Chun-Chieh Hsu and Yu-Ju Kuo

    Thrombosis Journal 2016 14(Suppl 1):18

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  10. Review

    New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2

    Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...

    Yukio Ozaki, Shogo Tamura and Katsue Suzuki-Inoue

    Thrombosis Journal 2016 14(Suppl 1):27

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  11. Review

    DOACs – advances and limitations in real world

    The group of new oral anticoagulants or NOACs, now termed direct oral anticoagulants or DOACs, with their favourable results from large scale phase III clinical trials, represent a major advancement and expand...

    Lai Heng Lee

    Thrombosis Journal 2016 14(Suppl 1):17

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  12. Review

    Management of venous thromboembolism: an update

    Venous thromboembolism (VTE), which constitutes pulmonary embolism and deep vein thrombosis, is a common disorder associated with significant morbidity and mortality. Landmark trials have shown that direct ora...

    Siavash Piran and Sam Schulman

    Thrombosis Journal 2016 14(Suppl 1):23

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  13. Review

    Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

    Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury, platelet accumulation (i.e. adhesion and aggregation) constitutes the first wave of hemostasis. Blood coagulation, ...

    Xiaohong Ruby Xu, Naadiya Carrim, Miguel Antonio Dias Neves, Thomas McKeown, Tyler W. Stratton, Rodrigo Matos Pinto Coelho, Xi Lei, Pingguo Chen, Jianhua Xu, Xiangrong Dai, Benjamin Xiaoyi Li and Heyu Ni

    Thrombosis Journal 2016 14(Suppl 1):29

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  14. Review

    Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis

    Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropr...

    Hidesaku Asakura, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hideo Wada

    Thrombosis Journal 2016 14:42

    Published on: 28 September 2016

  15. Research

    Disseminated intravascular coagulation with the fibrinolytic phenotype predicts the outcome of patients with out-of-hospital cardiac arrest

    We tested the hypothesis that disseminated intravascular coagulation (DIC) during the early phase of post-cardiopulmonary resuscitation (CPR) is associated with systemic inflammatory response syndrome (SIRS), ...

    Takeshi Wada, Satoshi Gando, Yuichi Ono, Kunihiko Maekawa, Kenichi Katabami, Mineji Hayakawa and Atsushi Sawamura

    Thrombosis Journal 2016 14:43

    Published on: 21 September 2016

  16. Case report

    A case report of asymptomatic aortic thrombosis incidentally detected by computed tomography in apparently healthy subject with a history of cancer surgery

    Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow’s ...

    Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Shunsuke Murai and Nobuyuki Ohte

    Thrombosis Journal 2016 14:16

    Published on: 2 August 2016

  17. Review

    Vitamin K antagonist use: evidence of the difficulty of achieving and maintaining target INR range and subsequent consequences

    Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR...

    Jeff R. Schein, C. Michael White, Winnie W. Nelson, Jeffrey Kluger, Elizabeth S. Mearns and Craig I. Coleman

    Thrombosis Journal 2016 14:14

    Published on: 13 June 2016

  18. Research

    Clinical benefit of graduated compression stockings for prevention of venous thromboembolism after total knee arthroplasty: post hoc analysis of a phase 3 clinical study of edoxaban

    Guidelines from the Japanese Circulation Society recommend prophylaxis with anticoagulation plus intermittent pneumatic compression or graduated compression stockings (GCS) among patients at the highest risk f...

    Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe, Shintaro Tachibana and Mashio Nakamura

    Thrombosis Journal 2016 14:13

    Published on: 8 June 2016

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