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Table 3 Laboratory parameters values

From: Multivariate relationships between international normalized ratio and vitamin K-dependent coagulation-derived parameters in normal healthy donors and oral anticoagulant therapy patients

 

group I (n = 35)

group II (n = 73)

group III (n = 95)

cut-off point

PT [sec]

11.3 (10.8–12.3)

10.8 (10.4–11.6)

24.0 a(20.4–29.4)

13.21 (0.979, 0.990)

INR

1.02 (0.98–1.11)

0.98 (0.92–1.04)

2.16 a(1.84–2.60)

1.20 (0.979, 0.990)

APTT ratio

1.01 (0.96–1.10)

0.98 (0.92–1.10)

1.17 a(1.08–1.33)

1.03 (0.870, 0.645)

Fibrinogen [g/l]

3.36 (2.85–3.83)

3.60 (3.19–4.09)

4.17 b(3.59–4.63)

4.13 (0.537, 0.815)

FII [%]

132 (117–142)

133 (122–145)

25 a(19–35)

83.0 (0.989, 0.971)

FVII [%]

125 (108–133)

135 (125–142)

47 a(32–64)

91.1 (0.946, 0.963)

FX [%]

108 (92–120)

104 (96–113)

15 a(11–20)

68.1 (1.0, 0.942)

protein C [%]

118 (103–138)

125 (110–137)

54 a(46–64)

91.0 (0.968, 0.935)

prothrombin F1+2 [ng/ml]

0.87 (0.57–1.26)

1.26 c(0.98–1.71)

0.27 a(0.19–0.40)

0.528 (0.840, 0.934)

  1. Data represent median and 25–75 percentile range. Cut-off points between users (group III) and non-users of OAT (groups I and II) estimated by ROC curve analysis with an a priori weighing of sensitivity:specificity ratio equal 1.0; the post hoc sensitivity and specificity estimates given in parentheses. Significance of differences between groups estimated for normalized data by one-way ANOVA (p « 0.0001 for all variables) and Tukey's test for multiple comparisons: ap « 0.0001; bp < 0.0002; cp < 0.05.