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Table 3 Laboratory parameters values

From: Multivariate relationships between international normalized ratio and vitamin K-dependent coagulation-derived parameters in normal healthy donors and oral anticoagulant therapy patients

  group I (n = 35) group II (n = 73) group III (n = 95) cut-off point
PT [sec] 11.3 (10.8–12.3) 10.8 (10.4–11.6) 24.0 a(20.4–29.4) 13.21 (0.979, 0.990)
INR 1.02 (0.98–1.11) 0.98 (0.92–1.04) 2.16 a(1.84–2.60) 1.20 (0.979, 0.990)
APTT ratio 1.01 (0.96–1.10) 0.98 (0.92–1.10) 1.17 a(1.08–1.33) 1.03 (0.870, 0.645)
Fibrinogen [g/l] 3.36 (2.85–3.83) 3.60 (3.19–4.09) 4.17 b(3.59–4.63) 4.13 (0.537, 0.815)
FII [%] 132 (117–142) 133 (122–145) 25 a(19–35) 83.0 (0.989, 0.971)
FVII [%] 125 (108–133) 135 (125–142) 47 a(32–64) 91.1 (0.946, 0.963)
FX [%] 108 (92–120) 104 (96–113) 15 a(11–20) 68.1 (1.0, 0.942)
protein C [%] 118 (103–138) 125 (110–137) 54 a(46–64) 91.0 (0.968, 0.935)
prothrombin F1+2 [ng/ml] 0.87 (0.57–1.26) 1.26 c(0.98–1.71) 0.27 a(0.19–0.40) 0.528 (0.840, 0.934)
  1. Data represent median and 25–75 percentile range. Cut-off points between users (group III) and non-users of OAT (groups I and II) estimated by ROC curve analysis with an a priori weighing of sensitivity:specificity ratio equal 1.0; the post hoc sensitivity and specificity estimates given in parentheses. Significance of differences between groups estimated for normalized data by one-way ANOVA (p « 0.0001 for all variables) and Tukey's test for multiple comparisons: ap « 0.0001; bp < 0.0002; cp < 0.05.