independent variable

R
^{2}

β
_{s}

p

β
_{overall}

p


Fibrinogen

0.095

0.315 ± 0.068

5.91*10^{6}

0.002 ± 0.019

0.921

APTT ratio

0.396

0.631 ± 0.055

1.98*10^{23}

0.024 ± 0.023

0.301

Factor II

0.893

0.944 ± 0.024

0

0.277 ± 0.042

3.07*10^{10}

Factor VII

0.884

0.919 ± 0.028

0

0.310 ± 0.036

1.68*10^{15}

Factor X

0.874

0.935 ± 0.025

0

0.229 ± 0.040

3.98*10^{8}

Protein C

0.783

0.886 ± 0.033

0

0.083 ± 0.035

0.019

Prothrombin F1+2

0.671

0.820 ± 0.041

0

0.088 ± 0.030

0.004

 Model estimated for logtransformed data in all variables with the accepted value of λ = 0.1. The values in the columns 2 and 4 of the table refer to the standardized regression coefficients (b_{
i
}) in the individual regression models (β_{s} ± SE [β_{s}]) including the individual independent variables, or to the overall ridge multiple regression model (β_{overall} ± SE [β_{overall}]) comprising all examined independent variables. The values of the determination coefficients (R^{2}) denote the individual contributions of any given variable (estimated in single variable regression models) in explaining the overall INR variability; for the overall multiple regression model the corrected overall R^{2} = 0.9289; both individual and overall R^{2} were significant with p at least 0.0001. For the model of a ridge multiple regression with INR as a dependent variable and comprising all the independent variables the partial correlation coefficients r_{p} are given in fig. 2.