Figure 1

Structure-activity relationships of SMTP congeners. (A) Structures of SMTP congeners tested. The core unit of SMTP congeners is represented by R. (B) The activation of plasminogen was assayed in the presence of the indicated concentrations of SMTP congeners. Number in circle represents the SMTP number. Toco, α-tocopherol. Each value represents the mean ± SD from triplicate determinations. Relative to control values are shown. Summary of the results are shown in the right panel, where EC₁₀ represents the concentration (μM) of SMTP that causes 10-fold enhancement of plasminogen activation and E_max the maximum level of the enhancement (fold increase in plasminogen activation compared with control). E_max and the reciprocal of EC₁₀ are independent indexes that represent the potency of the compound. The ratio E_max/EC₁₀ represents comprehensive potency. NA, not available (due to that enhancement did not reach 10-fold at concentrations tested).