Diastolic timed Vibro-Percussion at 50 Hz delivered across a chest wall sized meat barrier enhances clot dissolution and remotely administered Streptokinase effectiveness in an in-vitro model of acute coronary thrombosis

Table 5 Summary of results (SK enriched group)

No.	Donor	Treatment	Lytic Dist	Pre-Wt.	Post Wt.	(%)	R.M.S.	Channels	(min)	Mobilized	Fragmented
1	AH	Control	2.1 cm	0.258	0.254	2	+1	No	-	No	No
2	AH	Vibrate	2.0 cm	0.297	0.184	38	+5	Yes	10	No	No
3	HG	Vibrate	2.0 cm	0.295	0.177	40	+5	Yes	10	No	No
4	HG	Control	2.1 cm	0.288	0.280	3	+1	No	-	No	No
5	AH	Vibrate	1.5 cm	0.371	0.206	44	+6	Yes	10	No	No
6	AH	Vibrate	2.5 cm	0.255	0.126	51	+4¹	Yes	5	No	No
7²	HG	Vibrate	1.5 cm	0.352	0.161	54	+5	Yes	10	No	No
8	HG	Control	2.3 cm	0.262	0.246	6	+0³	No	-	No	No
9	AH	Vibrate	2.5 cm	0.236	0.061	74	+6	Yes	5	Yes	No
10	AH	Control	1.5 cm	0.453	0.436	4	+1	No	-	No	No
11	HG	Vibrate	1.8 cm	0.303	0.125	59	+5	Yes	5	No	No
12	AH	Control	2.1 cm	0.286	0.280	2	+1	No	-	No	No
13	HG	Control	1.9 cm	0.299	0.290	3	+1	No	-	No	No
14	HG	Control	1.6 cm	0.341	0.338	1	+1	No	-	No	No
15	AH	Vibrate	2.3 cm	0.255	0.133	48	+5	Yes	5	No	No
16	HG	Control	2.3 cm	0.259	0.251	3	+1	No	-	No	No

Results of; initial lytic to clot separation distance (cm), Percent Clot Dissolution (%), Relative Mixing Score (+0 - +7), clot length fluid channel development (Yes or No), time to first observation of clot length fluid channels (min), clot mobilization (Yes or No) and clot fragmentation (Yes vs. No), in view of a 20 minute exposure of remotely administered SK in conjunction with “diastolic” timed LFVP (Vibrate) vs. no LFVP (Control). Donors, AH = Andrew Hoffmann (male), HG=Harjit Gill (female).
¹Diminished mixing score in this sample was likely attributed to the relatively small initial clot size (with a leading edge ~2.5 cm from SK).
²This sample run developed a significant leak between the connecting line and blue tip connector of the catheter segment which could not be corrected. Only about 10 minutes of effective LFVP therapy was administered. Mixing score was based on maximum observed prior to the leak.
³Relatively low mixing score in this sample may have also been attributed to a relatively small clot size (with leading edge 2.3 cm from SK).

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