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Table 6 Contraindications to pharmacological TP or heparin dosage adjustment necessity †

From: Cross-sectional study of adherence to venous thromboembolism prophylaxis guidelines in hospitalized patients. The Trombo-Brit study

 

Total (n=322)

Medical (n=219)

Surgical (n=103)

Severe renal failure (ClCreat ≤ 30 ml/min) ¥

15 (4.7%)

14 (6.45%)

1 (1.01%)

Thrombocytopenia (<50000/mm 3 )

21 (6.52%)

21 (9.59%)

0

CNS hemorrhage in previous 7 days

4 (1.24%)

4 (1.83%)

0

Severe liver failure

7 (2.17%)

6 (2.74%)

1 (0.97%)

Suspected or active bleeding

9 (2.8%)

9 (4.11%)

0

Known bleeding diathesis

3 (0.93%)

2 (0.91%)

1 (0.97%)

TOTAL patients with contraindications

35 (11%)

32 (14.6)

3 (2.9)

  1. TP: thromboprophylaxis, ClCreat: creatinine clearence, CNS: central nervous system.
  2. † Some patients had more than one risk factor for bleeding.
  3. ¥ Adjustments required and/or change of drug. Calculations made on 316 patients (n=217 medical group and n=99 in the surgical group).