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Table 2 Effect of type of anaesthesia on outcomes: event rates observed with the different types of anaesthesia in the overall study population

From: Type of anaesthesia and the safety and efficacy of thromboprophylaxis with enoxaparin or dabigatran etexilate in major orthopaedic surgery: pooled analysis of three randomized controlled trials

Outcome General anaesthesia Neuraxial anaesthesia Combination
Major VTE and VTE-related mortality 4.2%* 3.1%* 3.1%
(73/1731) (101/3305) (35/1147)
MBE 1.2% 1.4% 1.2%
  (27/2311) (59/4212) (19/1539)
MBE/CRBE 4.9% 5.6% 5.7%
  (114/2311) (237/4212) (88/1539)
  1. *Only significantly different odds ratio (general versus neuraxial): 1.40 (95% confidence interval: 1.03–1.90, p = 0.035); all other comparisons are not significant.
  2. VTE, venous thromboembolism; MBE, major bleeding event; CRBE, clinically relevant bleeding events.