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Table 3 One-way Sensitivity analysis results

From: Dabigatran versus warfarin under standard or pharmacogenetic-guided management for the prevention of stroke and systemic thromboembolism in patients with atrial fibrillation: a cost/utility analysis using an analytic decision model

Parameter Option Cost/patient ∆ cost QALY ∆ QALY ICUR
76.8% of Patient TTR with warfarin pharmacogenetic guided dosing Warfarin standard 7289   3,5358   
Warfarin genetic testing 7611 322 3,6348 0,099 3253
Dabigatran 150 8494 883 3,7897 0,1549 5700
RR major hemorragic event dabigatran 150 vs warfarin = 0,81 warfarin standard 7289   3,5358   
warfarin genetic testing 7749 460 3,5453 0,0085 Dominated
Dabigatran 150 8142 393 3,8667 0,3214 2586
RR major hemorragic event dabigatran 150 vs warfarin = 1,07 warfarin standard 7289   3,5358   
warfarin genetic testing 7749 460 3,5453 0,0085 Dominated
Dabigatran 150 8879 1130 3,695 0,1497 9987
RR stroke dabigatran 150 VS warfarin = 0,82 warfarin standard 7289   3,5358   
warfarin genetic testing 7749 460 3,5453 0,0085 Dominated
Dabigatran 150 8765 1016 3,708 0,1627 8570
RR stroke dabigatran 150 VS warfarin = 0,53 warfarin standard 7289   3,5358   
warfarin genetic testing 7749 460 3,5453 0,0085 Dominated
Dabigatran 150 8298 549 3,8113 0,2755 3660
Cost genetic tests = CAD$ 100 warfarin standard 7289   3,5368   
warfarin genetic testing 7330 41 3.5453 0,0085 Dominated
dabigatran 150 8494 1164 3.7897 0,2444 4765
Cost genetic tests = CAD$ 1000 warfarin standard 7289   3,5368   
warfarin genetic testing 8050 41 3.5453 0,0085 Dominated
dabigatran 150 8494 1164 3.7897 0,2444 4765
Day cost of dabigatran 150 = 1CAD$ Dabigatran 150 5217   3.7897   
Warfarin standard 7289 2072 3.5368 −0,2444 Dominated
Warfarin genetic testing 7749 460 3.5453 −0,0085 Dominated
Day cost of dabigatran 150 = 5$ Warfarin standard 7289   3,5368   
Warfarin genetic testing 7749 460 3.5453 0,0085 Dominated
Dabigatran 150 mg 11182 1164 3.7897 0,2444 15393
Utility score dabigatran without event =0,98 warfarin standard 7289   3,5358   
  warfarin genetic testing 7749 460 3,5453 0,0085 Dominated
  Dabigatran 150 8494 745 3,902 0,3567 3290