Dabigatran versus warfarin under standard or pharmacogenetic-guided management for the prevention of stroke and systemic thromboembolism in patients with atrial fibrillation: a cost/utility analysis using an analytic decision model

Nshimyumukiza, Léon; Duplantie, Julie; Gagnon, Mathieu; Douville, Xavier; Fournier, Diane; Lindsay, Carmen; Parent, Marc; Milot, Alain; Giguère, Yves; Gagné, Christian; Rousseau, François; Reinharz, Daniel

doi:10.1186/1477-9560-11-14

Table 3 One-way Sensitivity analysis results

From: Dabigatran versus warfarin under standard or pharmacogenetic-guided management for the prevention of stroke and systemic thromboembolism in patients with atrial fibrillation: a cost/utility analysis using an analytic decision model

Parameter	Option	Cost/patient	∆ cost	QALY	∆ QALY	ICUR
76.8% of Patient TTR with warfarin pharmacogenetic guided dosing	Warfarin standard	7289		3,5358
	Warfarin genetic testing	7611	322	3,6348	0,099	3253
	Dabigatran 150	8494	883	3,7897	0,1549	5700
RR major hemorragic event dabigatran 150 vs warfarin = 0,81	warfarin standard	7289		3,5358
	warfarin genetic testing	7749	460	3,5453	0,0085	Dominated
	Dabigatran 150	8142	393	3,8667	0,3214	2586
RR major hemorragic event dabigatran 150 vs warfarin = 1,07	warfarin standard	7289		3,5358
	warfarin genetic testing	7749	460	3,5453	0,0085	Dominated
	Dabigatran 150	8879	1130	3,695	0,1497	9987
RR stroke dabigatran 150 VS warfarin = 0,82	warfarin standard	7289		3,5358
	warfarin genetic testing	7749	460	3,5453	0,0085	Dominated
	Dabigatran 150	8765	1016	3,708	0,1627	8570
RR stroke dabigatran 150 VS warfarin = 0,53	warfarin standard	7289		3,5358
	warfarin genetic testing	7749	460	3,5453	0,0085	Dominated
	Dabigatran 150	8298	549	3,8113	0,2755	3660
Cost genetic tests = CAD$ 100	warfarin standard	7289		3,5368
	warfarin genetic testing	7330	41	3.5453	0,0085	Dominated
	dabigatran 150	8494	1164	3.7897	0,2444	4765
Cost genetic tests = CAD$ 1000	warfarin standard	7289		3,5368
	warfarin genetic testing	8050	41	3.5453	0,0085	Dominated
	dabigatran 150	8494	1164	3.7897	0,2444	4765
Day cost of dabigatran 150 = 1CAD$	Dabigatran 150	5217		3.7897
	Warfarin standard	7289	2072	3.5368	−0,2444	Dominated
	Warfarin genetic testing	7749	460	3.5453	−0,0085	Dominated
Day cost of dabigatran 150 = 5$	Warfarin standard	7289		3,5368
	Warfarin genetic testing	7749	460	3.5453	0,0085	Dominated
	Dabigatran 150 mg	11182	1164	3.7897	0,2444	15393
Utility score dabigatran without event =0,98	warfarin standard	7289		3,5358
	warfarin genetic testing	7749	460	3,5453	0,0085	Dominated
	Dabigatran 150	8494	745	3,902	0,3567	3290

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ISSN: 1477-9560

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