Table 1 Influence of DOA on different coagulation assays
From: Main considerable factors for correct laboratory test interpretation under DOA treatment
Influence of DOA on coagulation parameters | |||
|---|---|---|---|
PT [INR or sec] | ↑ | ↑↑↑ | ↑↑ |
aPTT | ↑↑↑ | ↑↑ | ↑ |
Thrombin Time | ↑↑↑↑↑ | - | - |
Fibrinogen (Clauss method) derived Fibrinogen | ↓(↓) | - | - |
|  | (↑) | ↑ | (↑) |
Antithrombin FXa-based assay | - | ↑ | ↑ |
        FIIa-based assay | ↑ | - | - |
Intrinsic coagulation factors VIII, IX, XI, XII (based on aPTT) | ↓↓ | ↓ | ↓ |
Extrinisic coagulation factors II,V,VII,X (based on PT) | ↓ | ↓↓ | ↓↓ |
Factor XIII -photometric | ↓↓ | - | - |
     -immunologic | - | - | - |
Protein S (clotting) | ↑↑ | ↑↑ | ↑ |
Free Protein S antigen (immunologic) | - | - | - |
(chromogenic) | ↑↑ | ↑ | ↑ |
| Â | - | - | - |
Diluted Russel’s Viper Venom - test | ↑ | ↑↑↑ | ↑↑ |
Activated Protein C-Ratio (based on aPTT-assay) | ↑↑ | ↑ | ↑ |
Ecarin Clotting Time | ↑↑ | - | - |