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Table 1 Influence of DOA on different coagulation assays

From: Main considerable factors for correct laboratory test interpretation under DOA treatment

Influence of DOA on coagulation parameters
PT [INR or sec] ↑↑↑ ↑↑
aPTT ↑↑↑ ↑↑
Thrombin Time ↑↑↑↑↑ - -
Fibrinogen (Clauss method) derived Fibrinogen ↓(↓) - -
  (↑) (↑)
Antithrombin FXa-based assay -
        FIIa-based assay - -
Intrinsic coagulation factors VIII, IX, XI, XII (based on aPTT) ↓↓
Extrinisic coagulation factors II,V,VII,X (based on PT) ↓↓ ↓↓
Factor XIII -photometric ↓↓ - -
     -immunologic - - -
Protein S (clotting) ↑↑ ↑↑
Free Protein S antigen (immunologic) - - -
(chromogenic) ↑↑
  - - -
Diluted Russel’s Viper Venom - test ↑↑↑ ↑↑
Activated Protein C-Ratio (based on aPTT-assay) ↑↑
Ecarin Clotting Time ↑↑ - -