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Table 3 ROC-analysis of TG-derived parameters for the detection of previous thrombosis in samples from patients preselected by LAC Screen ratio (LAC screen ratio >= 1.2 and LAC screen ratio < 1.2)

From: Thrombin generation as marker to estimate thrombosis risk in patients with abnormal test results in lupus anticoagulant routine diagnostics

TG-derived parameter ROC (95% CI) (LAC-S ratio >=1.2) N = 29 Cases excluded ROC (95% CI) (LAC-S ratio <1.2) N = 34 Cases excluded
dRVVT 0.46 (0.24 - 0.68) none Not calculated Not determined
RC-low lag time 0.76 (0.56 - 0.97) 2 thrombosis 1 non-thrombosis 0.59 (0.36 - 0.82) 1 thrombosis
RC-low peak height of thrombin formation 0.80 (0.57 - 1.00) 2 thrombosis 1 non-thrombosis 0.51 (0.30 - 0.72) 1 thrombosis
RC-low time to peak 0.80 (0.58 - 1.00) 2 thrombosis 1 non-thrombosis 0.50 (0.27 - 0.73) 1 thrombosis
RC-low AUC 0.81 (0.57 - 1.00) 2 thrombosis 1 non-thrombosis 0.57 (0.35 - 0.78) 1 thrombosis
RC-high lag time 0.83 (0.68 - 0.98) 2 thrombosis 0.72 (0.53 - 0.91) 1 thrombosis
RC_high peak height of thrombin formation 0.82 (0.60 - 1.00) 2 thrombosis 0.61 (0.39 - 0.83) 1 thrombosis
RC_high time to peak 0.80 (0.61 - 0.99) 2 thrombosis 0.70 (0.50 - 0.90) 1 thrombosis
RC-high AUC 0.83 (0.60 - 1.00) 2 thrombosis 0.67 (0.46.- 0.87) 1 thrombosis