Serial changes in coagulation tests in the two groups. Data are expressed as group means ± standard deviation. There were no interaction between treatment and time in D-dimer (p = 0.289), Prothrombin time ratio (p = 0.457) and Fibrinogen level (p = 0.528). *p < 0.01 compared with the control group. †p < 0.05 compared with baseline.