Table 1 Characteristics and diagnostic data of the patients
Control group (n = 23) | Treatment group (n = 12) | P value | |
|---|---|---|---|
Age | 70.9 ± 13.7 | 60.6 ± 19.2 | 0.117 |
Male (%) | 16 (69.6) | 8 (66.7) | 0.919 |
APACHE II score | 29.2 ± 8.5 | 26.6 ± 8.6 | 0.395 |
SOFA score (day 1) | 11.7 ± 3.4 | 10.5 ± 2.5 | 0.418 |
Number of dysfunctional organs | 3.7 ± 1.0 | 3.5 ± 0.7 | 0.450 |
Shock | 11 (47.8) | 5 (41.7) | 0.728 |
AKI | 13 (56.5) | 5 (41.7) | 0.404 |
ARDS | 15 (65.2) | 8 (66.7) | 0.618 |
DIC score (day 1) | 5.8 ± 1.2 | 5.7 ± 1.4 | 0.881 |
DIC score (max) | 6.7 ± 1.02 | 6.33 ± 1.33 | 0.703 |
ISTH criteria (%) | 9 (39.1) | 5 (41.7) | 0.884 |
Platelet count (103/μl) | 94.3 ± 49.6 | 65.6 ± 48.3 | 0.130 |
Prothrombin time ratio | 1.52 ± 0.39 | 1.48 ± 0.41 | 0.759 |
D-dimer (mg/ml) | 26.9 ± 35.3 | 55.1 ± 133.1 | 0.486 |
AT III activity (%) | 51.3 ± 19.0 | 61.3 ± 20.5 | 0.264 |
Renal replacement therapy (%) | 13 (56.5) | 8 (66.7) | 0.559 |
Mechanical ventilation (%) | 23 (100) | 12 (100) | - |
Use of vasopressor (%) † | 21 (91.3) | 10 (83.3) | 0.482 |
Use of low-dose steroid (%) | 1 (4.35) | 1 (8.33) | 0.630 |
Use of AT III (%) | 16 (69.6) | 5 (41.7) | 0.111 |
Use of Platelet concentrate (%) | 10 (43.5) | 8 (66.7) | 0.189 |
Use of fresh frozen plasma (%) | 15 (65.2) | 8 (66.7) | 0.932 |
Positive blood culture (%) | 7 (31.8)* | 7 (58.3) | 0.134 |
Period for rhTM administration (day) | - | 5.8 ± 1.3 | - |
Sites of infection | |||
Lung (%) | 9 (39.1) | 4 (33.3) | 0.735 |
Abdomen (%) | 7 (30.4) | 4 (33.3) | 0.735 |
Urinary tract (%) | 2 (8.7) | 2 (16.7) | 0.364 |
Other (%) | 5 (21.8) | 3 (25.0) | 0.203 |