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Table 1 Characteristics and diagnostic data of the patients

From: Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation and mortality: a retrospective cohort study

  Control group (n = 23) Treatment group (n = 12) P value
Age 70.9 ± 13.7 60.6 ± 19.2 0.117
Male (%) 16 (69.6) 8 (66.7) 0.919
APACHE II score 29.2 ± 8.5 26.6 ± 8.6 0.395
SOFA score (day 1) 11.7 ± 3.4 10.5 ± 2.5 0.418
Number of dysfunctional organs 3.7 ± 1.0 3.5 ± 0.7 0.450
Shock 11 (47.8) 5 (41.7) 0.728
AKI 13 (56.5) 5 (41.7) 0.404
ARDS 15 (65.2) 8 (66.7) 0.618
DIC score (day 1) 5.8 ± 1.2 5.7 ± 1.4 0.881
DIC score (max) 6.7 ± 1.02 6.33 ± 1.33 0.703
ISTH criteria (%) 9 (39.1) 5 (41.7) 0.884
Platelet count (103/μl) 94.3 ± 49.6 65.6 ± 48.3 0.130
Prothrombin time ratio 1.52 ± 0.39 1.48 ± 0.41 0.759
D-dimer (mg/ml) 26.9 ± 35.3 55.1 ± 133.1 0.486
AT III activity (%) 51.3 ± 19.0 61.3 ± 20.5 0.264
Renal replacement therapy (%) 13 (56.5) 8 (66.7) 0.559
Mechanical ventilation (%) 23 (100) 12 (100) -
Use of vasopressor (%) 21 (91.3) 10 (83.3) 0.482
Use of low-dose steroid (%) 1 (4.35) 1 (8.33) 0.630
Use of AT III (%) 16 (69.6) 5 (41.7) 0.111
Use of Platelet concentrate (%) 10 (43.5) 8 (66.7) 0.189
Use of fresh frozen plasma (%) 15 (65.2) 8 (66.7) 0.932
Positive blood culture (%) 7 (31.8)* 7 (58.3) 0.134
Period for rhTM administration (day) - 5.8 ± 1.3 -
Sites of infection    
   Lung (%) 9 (39.1) 4 (33.3) 0.735
   Abdomen (%) 7 (30.4) 4 (33.3) 0.735
   Urinary tract (%) 2 (8.7) 2 (16.7) 0.364
   Other (%) 5 (21.8) 3 (25.0) 0.203
  1. No significant differences were observed between the control and treatment groups.
  2. *Blood culture was not performed in one patient.
  3. Vasopressors not only were used for sepsis but also before the onset of sepsis-induced DIC and were used to maintain circulation for surgery.