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Table 2 Time in range and percentage of INR values in range and major adverse event rates

From: Quality of vitamin K antagonist control and outcomes in atrial fibrillation patients: a meta-analysis and meta-regression

Study, year N TTR, % PINRR, % Event rate, % per patient-year
   In range Below range Above range In range Below range Above range Bleeding ICH Ischemic stroke
Abdelhafiz 2004 [11] 402 66 19.7 14.3 - - - 1.7 - -
Abdelhafiz (<75) 2008 [12] 203 58 16 26 - - - 1.6 0 -
Abdelhafiz (≥75) 2008 [12] 199 58 16 26 - - - 1.9 0 -
Albers 2005 [14] 1962 68 20 12 - - - 2.8 0.2 1.1
Anderson 2004 [15] 87 - - - 60.4 25.2 14.3 -   
Ansell (Italy) 2007 [16] 177 68.9 21 10.1 60 26.3 13.6 - - -
Ansell (Spain) 2007 [16] 218 64.4 18.6 17 59 23.3 17.7 - - -
Ansell (US) 2007 [16] 686 57 29.1 13.9 50.8 32 17.3 - - -
Ansell (Canada) 2007 [16] 152 61 25.9 13.1 58.4 27.6 14 - - -
Ansell (France) 2007 [16] 278 58.1 15.4 26.5 51.3 19.7 29 - - -
Aronow 1999 [17] 125 - - - 68 26 6 - - 11.3
Boulanger 2006 [18] 6454 48 38 14 - - - 2.8 - -
Burton (<75) 2006 [19] 260 68 17 15 - - - 2.8   
Burton (>75) 2006 [19] 341 68 19 13 - - - 2.4
Cafolla (Manual) 2011 [20] 576 60.4 - - - - - - - -
Cafolla 2012 [21] 57 64.4 - - - - - 0 - -
Chung 2011 [23] 75 45.1 43.9 10.9 - - - 10.5 0 0
Connolly 1991 [24] 187 43.7 39.6 16.6 - - - 2.1 0.4 2.1
Connolly 2006 [25] 3371 63.8 20.8 15.4 - - - 2.2 - 1.0
Currie (stable) 2005 [27] 787 74.9 - - - - - 0.4 - -
Currie (unstable) 2005 [27] 726 55.7 - - - - - 1.2 - -
Dimberg (UC) 2012 [30] 84 64.3 - - - - - - - -
Dimberg (ACC) 2012 [30] 271 73.6 - - - - - - - -
Ellis 2009 [32] 66 71.4 - - 70.7 16.0 13.3 5.8   
Evans 2000 [33] 288 55 26 19 - - - 3.1 0.5 5.5
Evans 2001 [34] 214 66 - - - - - 3.1 0.7 4.2
Ezekowitz 2007 [35] 70 57.2 - - - - - 0 - -
Gallagher 2011 [37] 18113 63.1 20.7 16.2 - - - - - -
Garcia (naïve) 2013 [38] 3888 61.4 - - - - - 3.0 0.8 -
Garcia (exp) 2013 [38] 5193 69.1 - - - - - 3.2 0.8 -
Go 2003 [40] 7445 62.5 26.8 10.7 - - - 1.5 0.4 1.1
Gullov 1998 [41] 170 73 18 9 - - - 1.1 0.6 0.8
Gurwitz 1997 [43] 117 39.6 44.8 15.6 - - - - - -
Heidinger 2000 [46] 753 - - - 69.5 23.5 7.0 1.7 - -
Ho (HTN) 2011 [48] 278 49.7 45.4 4.9 - - - 1.7 0.5 2.2
Ho (no HTN) 2011 [48] 198 49.8 44.2 6.0 - - -
Holmes 2009 [49] 244 66 - - - - - 2.7 - 1.6
Hori 2012 [50] 250 - - - 51.8 43.8 4.2 0.8   0.3
Hylek 2007 [52] 472 58 29 11 - - - 7.2 2.5 -
Jacobs 2009 [53] 90 49 35 15 - - - 5.6   
Jones 2005 [54] 2223 68.9 16.7 15.4 53.4 - - - - -
Kalra 2000 [55] 167 61 26 13 - - - 1.4 0.3 2.0
Kim 2009 [56] 129 - - - 60.9 31.2 9.1 0   
Kim 2010 [57] 499 73.4 - - - - - - - -
Kulo (warfarin) 2009 [58] 60 - - - 51.8 42.8 5.4 - - -
Kulo (acenocoum) 2009 [58] 57 - - - 53.6 35.9 10.5 - - -
Lee 2012 [59] 200 48.5 - - - - - 6.6 - -
Malik (AF) 2000 [60] 247 58.9 27.4 14.1 - - - - - -
Mant 2007 [61] 488 67 19 14 - - - 1.9 - 0.8
Matchar (control) 2002 [62] 317 52.3 31.8 15.9 - - - 2.1 - -
Matchar (ACC) 2002 [62] 363 55.6 31.2 13.1 - - - 2.2 - -
McBride 2007 [63] 361 56 16 28 - - - - - -
McCormick 2001 [64] 174 51 36 13 - - - - - -
Melamed 2011 [65] 906 48.6 32.0 19.3 - - - - - -
Menzin 2005 [66] 600 62 25 13 - - - 3.6 - 1.0
Neree 2006 [68] 395 53 - - 52.8 8.7 38.5 4.4 - -
Nichol (ACC) 2008 [69] 351 68 21 11 - - - 2.3 - -
Nichol (UC) 2008 [69] 756 42 49 9 - - - 6.3 - -
Njaastad 2006 [70] 421 71.5 - - - - - 0.8 - -
Okumura (<70) 2011 [73] 208 46 51 2 - - - - - -
Olsson 2003 [74] 1703 66 - - - - - 2.2 - 1.9
Patel 2011 [76] 7133 55 - - - - - 3.4 0.7 -
Pengo 1998 [77] 153 70 18 12 - - - 2.8 0.6 0
Pengo 2010 [79] 132 65 25 9 - - - 3.0 - -
Perez-Gomez 2004 [80] 237 65 19 16 - - - 1.8   
Poli 2007 [81] 290 69 15 16 - - - 2.1 1.4 -
Poli 2009 [82] 783 71 14 15 - - - 1.4 0.7 0.9
Poli 2009 [83] 578 68 16 16 - - - - - -
Poller (Manual) 2008 [85] 2967 66.2 - - - - - - - -
Samsa (ACC) 2000 [87] 43 60.3 25.9 13.8 54.9 26.7 18.3 - - -
Samsa (Rochester) 2000 [87] 61 46.9 33.9 19.3 43.6 33.5 22.9 - - -
Samsa (R. Triangle) 2000 [87] 125 35.6 52.1 12.2 34.2 51.0 14.8 - - -
Sconce (vitamin K) 2007 [89] 35 87 - - - - - - - -
Sconce (placebo) 2007 [89] 35 78 - - - - - - - -
Shen 2007 [90] NR 54.5 36.3 9.2 - - - - 0.5 -
SPAF III 1996 [92] 523 - - - 61 25 14    
Sullivan (women) 2012 [93] 1594 60 29 11 - - - - - 0.8
Sullivan (men) 2012 [93] 2466 63 26 14 - - - - - 0.5
Tincani 2009 [94] 90 66 19 14 - - - 5.5 3.3 2.2
Van Spall 2012 [95] 6022 64 22 13 - - - - - -
Voller (self-mgmt) 2005 [96] 101 72.4 13.6 14 67.8 15.2 17.0 2.9 - -
Voller (UC) 2005 [96] 101 63.6 19.5 16.9 58.5 22.1 19.4 0 - -
Walker (MHC) 2011 [97] 22 56.8 34.2 9.0 - - - - - -
Walker (no MHC) 2011 [97] 62 65.9 30.7 3.4 - - - - - -
Wieloch (AF) 2011 [98] 11770 76.5 - - - - - 2.6 - -
Weitz 2010 [99] 250 49.7 - - - - - 1.6 - -
Yousef 2004 [103] 739 - - - 62.8 22.9 14.3 1.9 - -
  1. AC = Anticoagulation; AF = atrial fibrillation; ICH = Intracranial Hemorrhage; HTN = Hypertension, INR = international normalized ratio; MGMT = Management; N = Number; SP = Standard Practice; TTR = time in the therapeutic range; PINRR = proportion of INR Measurements in range.