Drug-drug interactions and risk of bleeding among inpatients on warfarin therapy: a prospective observational study

Table 3 List of drugs interacting with warfarin

Drug class	Drugs	No. of patients	Level of interaction	Drug class	Drugs	No. of patients	Level of interaction
Antibiotics	Ceftriaxone	30	Moderate	Anticoagulants	Heparin	101	Moderate
	Cotrimoxazole	22	Major		Enoxaparine	1	Major
	Nevirapine	14	Moderate		Enoxaparine	1	Major
	Clarithromycin	11	Major	Cardiovascular	Spironolactone	33	Moderate
	Rifampin,	18	Moderate		Atenolol	9	Moderate
	Isoniazid	18	Moderate		Propranolol	3	Moderate
	Norfloxacin,	8	Major		Amiodarone	1	Major
	Benzathine penicillin	8	Major
	Ciprofloxacin	6	Major	Acid suppressing agents	Omeprazole	18	Moderate
	Ciprofloxacin	6	Major		Cimetidine	15	Moderate
	Amoxicillin	4	Major		Pantoprazole	1	Moderate
	Metronidazole	3	Major
	Ceftazidime	2	Major
	Cephalexin	2	Major
	Cloxacillin	2	Major	Analgesics	Aspirin	20	Major
	Vancomycin	1	Moderate		Diclofenac	9	Moderate
	Erythromycin	1	Major		Ibuprofen	1	Moderate
	Cefotaxime	1	Major		Acetaminophen	2	Moderate
	Miconazole	6	Major		Tramadol	20	Moderate
	Fluconazole	1	Major		Tramadol	20	Moderate
				Corticosteroids	Prednisolone	3	Moderate
					Dexamethasone	2	Moderate
					Hydrocortisone	1	Moderate
Lipid lowering	Simvastatin	20	Major	Others	Amitriptyline	2	Moderate
					Propylthiouracil	1	Moderate
					Glibenclamide	1	Moderate
Anti-epileptic	Phenobarbitone	2	Moderate		Lactulose	1	Major
	Na valproate	2	Major
	Phenytoin	1	Moderate

ISSN: 1477-9560