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Table 3 List of drugs interacting with warfarin

From: Drug-drug interactions and risk of bleeding among inpatients on warfarin therapy: a prospective observational study

Drug class Drugs No. of patients Level of interaction Drug class Drugs No. of patients Level of interaction
Antibiotics Ceftriaxone 30 Moderate Anticoagulants Heparin 101 Moderate
Cotrimoxazole 22 Major Enoxaparine 1 Major
Nevirapine 14 Moderate
Clarithromycin 11 Major Cardiovascular Spironolactone 33 Moderate
Rifampin, 18 Moderate Atenolol 9 Moderate
Isoniazid 18 Moderate Propranolol 3 Moderate
Norfloxacin, 8 Major Amiodarone 1 Major
Benzathine penicillin 8 Major     
Ciprofloxacin 6 Major Acid suppressing agents Omeprazole 18 Moderate
Cimetidine 15 Moderate
Amoxicillin 4 Major Pantoprazole 1 Moderate
Metronidazole 3 Major
Ceftazidime 2 Major
Cephalexin 2 Major
Cloxacillin 2 Major Analgesics Aspirin 20 Major
Vancomycin 1 Moderate Diclofenac 9 Moderate
Erythromycin 1 Major Ibuprofen 1 Moderate
Cefotaxime 1 Major Acetaminophen 2 Moderate
Miconazole 6 Major Tramadol 20 Moderate
Fluconazole 1 Major
    Corticosteroids Prednisolone 3 Moderate
Dexamethasone 2 Moderate
Hydrocortisone 1 Moderate
Lipid lowering Simvastatin 20 Major Others Amitriptyline 2 Moderate
Propylthiouracil 1 Moderate
Glibenclamide 1 Moderate
Anti-epileptic Phenobarbitone 2 Moderate Lactulose 1 Major
Na valproate 2 Major
Phenytoin 1 Moderate