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Table 4 Summary of pharmacokinetic and pharmacodynamic drug interactions with rivaroxaban[12, 13, 25, 47–50]

From: Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban: considerations for the treatment of venous thromboembolism

Medication class and drug name

Extent of drug–drug interaction with rivaroxaban

 

None/not clinically relevant (routine co-administration possible)

Moderate clinical relevance (co-administer with caution)

High clinical relevance (avoid co-administration)

HIV protease inhibitors

   

 Ritonavir

  

X

Azole-antimycotics

   

 Ketoconazole

  

X

 Fluconazole

 

X

 

Antibiotics

   

 Clarithromycin

X

  

 Erythromycin

X

  

 Rifampicin

 

X

 

Anticoagulants

   

 Enoxaparin

  

X

 Warfarin

  

Xa

NSAIDs and platelet inhibitors

   

 Naproxen

 

X

 

 Clopidogrel

 

X

 

 Aspirin

 

X

 

Cardiac medications

   

 Digoxin

X

  

 Atorvastatin

X

  

 Dronedarone

  

Xb

Stomach acid regulators

   

 Ranitidine

X

  

 Aluminium-magnesium hydroxide (antacid)

X

  

Sedatives

   

 Midazolam

X

  

Antidepressants

   

 St John’s wort

 

X

 

Anticonvulsants

   

 Phenytoin

 

X

 

 Carbamazepine

 

X

 

 Phenobarbital

 

X

 
  1. aExcept when switching; bbased on a lack of clinical information.
  2. HIV, human immunodeficiency virus; NSAID, non-steroidal anti-inflammatory drug.