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Table 4 Summary of pharmacokinetic and pharmacodynamic drug interactions with rivaroxaban[12, 13, 25, 4750]

From: Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban: considerations for the treatment of venous thromboembolism

Medication class and drug name Extent of drug–drug interaction with rivaroxaban
  None/not clinically relevant (routine co-administration possible) Moderate clinical relevance (co-administer with caution) High clinical relevance (avoid co-administration)
HIV protease inhibitors    
 Ritonavir    X
Azole-antimycotics    
 Ketoconazole    X
 Fluconazole   X  
Antibiotics    
 Clarithromycin X   
 Erythromycin X   
 Rifampicin   X  
Anticoagulants    
 Enoxaparin    X
 Warfarin    Xa
NSAIDs and platelet inhibitors    
 Naproxen   X  
 Clopidogrel   X  
 Aspirin   X  
Cardiac medications    
 Digoxin X   
 Atorvastatin X   
 Dronedarone    Xb
Stomach acid regulators    
 Ranitidine X   
 Aluminium-magnesium hydroxide (antacid) X   
Sedatives    
 Midazolam X   
Antidepressants    
 St John’s wort   X  
Anticonvulsants    
 Phenytoin   X  
 Carbamazepine   X  
 Phenobarbital   X  
  1. aExcept when switching; bbased on a lack of clinical information.
  2. HIV, human immunodeficiency virus; NSAID, non-steroidal anti-inflammatory drug.