Medication class and drug name | Extent of drug–drug interaction with rivaroxaban | ||
---|---|---|---|
 | None/not clinically relevant (routine co-administration possible) | Moderate clinical relevance (co-administer with caution) | High clinical relevance (avoid co-administration) |
HIV protease inhibitors | Â | Â | Â |
 Ritonavir |  |  | X |
Azole-antimycotics | Â | Â | Â |
 Ketoconazole |  |  | X |
 Fluconazole |  | X |  |
Antibiotics | Â | Â | Â |
 Clarithromycin | X |  |  |
 Erythromycin | X |  |  |
 Rifampicin |  | X |  |
Anticoagulants | Â | Â | Â |
 Enoxaparin |  |  | X |
 Warfarin |  |  | Xa |
NSAIDs and platelet inhibitors | Â | Â | Â |
 Naproxen |  | X |  |
 Clopidogrel |  | X |  |
 Aspirin |  | X |  |
Cardiac medications | Â | Â | Â |
 Digoxin | X |  |  |
 Atorvastatin | X |  |  |
 Dronedarone |  |  | Xb |
Stomach acid regulators | Â | Â | Â |
 Ranitidine | X |  |  |
 Aluminium-magnesium hydroxide (antacid) | X |  |  |
Sedatives | Â | Â | Â |
 Midazolam | X |  |  |
Antidepressants | Â | Â | Â |
 St John’s wort |  | X |  |
Anticonvulsants | Â | Â | Â |
 Phenytoin |  | X |  |
 Carbamazepine |  | X |  |
 Phenobarbital |  | X |  |