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Table 1 Influence of factor X concentration on clotting test results

From: Simple and rapid assay for effect of the new oral anticoagulant (NOAC) rivaroxaban: preliminary results support further tests with all NOACs

  Undiluted Dilution Dilution Dilution Dilution Dilution Dilution p
Test 100% 50% 25% 12.50% 6.25% 3.13% 1.56%  
R-PT 1 1.18 ± 0.07 1.42 ± 0.04 1.84 ± 0.14 2.09 ± 0.2 2.71 ± 0.08 3.44 ± 0.25 <0.001
R-aPTT 1 0.99 ± 0.14 1.08 ± 0.11 1.22 ± 0.08 1.3 ± 0.1 1.55 ± 0.26 1.8 ± 0.30 <0.001
R-VV 1 1.13 ± 0.07 1.36 ± 0.07 1.55 ± 0.08 1.85 ± 0.11 2.19 ± 0.24 2.73 ± 0.28 <0.001
R-C 1 1.17 ± 0.11 1.46 ± 0.14 1.79 ± 0.12 2.35 ± 0.16 3.11 ± 0.16 4.52 ± 0.33 <0.001
P   0.034 <0.001 <0.001 <0.001 <0.001 <0.001  
  1. Dilution 50%: p < 0.05 for R-aPTT vs. R-PT, R-VV and R-C; Dilution 25%: p < 0.01 for R-aPTT vs. R-PT, R-VV, and R-C; Dilution 12,5%: p < 0.01 for R-aPTT vs. R-PT and R-C; p < 0.05 for R-aPTT vs. R-VV; p < 0.05 for R-VV vs. R-C and R-PT; Dilution 6.25%: p < 0.01 for R-C vs. R-aPTT; p < 0.05 for R-C vs. R-VV and R-PT; p < 0.01 for R-PT vs. R-aPTT; p < 0.05 for R-PT vs. R-VV; Dilution 3.13%: p < 0.01 for R-C vs. R-aPTT and R-VV; p < 0.05 for R-C vs. R-PT; p < 0.05 for RaPTT vs. R-VV and R-PT; Dilution 1.56%: p < 0.01 for R-C vs. R-aPTT, R-VV, and R-PT; p < 0.01 for R-aPTT vs. R-VV and R-PT.