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Table 1 Current approval of the NOACs

From: The role of prothrombin complex concentrates in reversal of target specific anticoagulants

  FDA Approval EMA Approval
Dabigatran -Stroke prevention in AF -VTE prevention after orthopedic surgery,
-Stroke prevention in AF
Rivaroxaban -Stroke prevention in AF, -VTE prevention afte orthopedic surgery
-VTE prevention after orthopedic surgery -Stroke prevention in AF
- VTE treatment
Apixaban -Stroke prevention in AF -VTE prevention after orthopedic surgery
-Stroke prevention in AF
  1. EMA = European Medicines Agency, AF = Non- valvular Atrial Fibrillation, VTE = Venous Thromboembolism to include Deep vein thrombosis and Pulmonary Embolism.