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Table 1 Current approval of the NOACs

From: The role of prothrombin complex concentrates in reversal of target specific anticoagulants

 

FDA Approval

EMA Approval

Dabigatran

-Stroke prevention in AF

-VTE prevention after orthopedic surgery,

-Stroke prevention in AF

Rivaroxaban

-Stroke prevention in AF,

-VTE prevention afte orthopedic surgery

-VTE prevention after orthopedic surgery

-Stroke prevention in AF

- VTE treatment

Apixaban

-Stroke prevention in AF

-VTE prevention after orthopedic surgery

-Stroke prevention in AF

  1. EMA = European Medicines Agency, AF = Non- valvular Atrial Fibrillation, VTE = Venous Thromboembolism to include Deep vein thrombosis and Pulmonary Embolism.