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Table 4 Influence of platelet concentration on the normal values of thrombin generation parameters assessed by Thrombogram-Thrombinoscope in the presence of 1/2000 final dilution of recombiplastin corresponding to estimated TF concentration of 3 pM. (n = 7; means ± sd, *p < 0,05 versus the respective value in the presence of platelet counts 10 × 109/l.

From: Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Platelet concentration (× 109/l)

lag-time (min)

Tmax (min)

Cmax (nM)

ETP (nM × min)

400

5 ± 0,5

11 ± 2,7

161 ± 38

1633 ± 81

150

5,5 ± 0,5

11 ± 0,2

98 ± 40

1316 ± 255*

100

5,8 ± 0,7*

13 ± 0,9

72 ± 38

1135 ± 300

50

8 ± 3,3

12 ± 0,2*

63 ± 14*

1095 ± 301

10

8 ± 3

19 ± 2

43 ± 16

894 ± 100