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Table 4 Influence of platelet concentration on the normal values of thrombin generation parameters assessed by Thrombogram-Thrombinoscope in the presence of 1/2000 final dilution of recombiplastin corresponding to estimated TF concentration of 3 pM. (n = 7; means ± sd, *p < 0,05 versus the respective value in the presence of platelet counts 10 × 109/l.

From: Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Platelet concentration (× 109/l) lag-time (min) Tmax (min) Cmax (nM) ETP (nM × min)
400 5 ± 0,5 11 ± 2,7 161 ± 38 1633 ± 81
150 5,5 ± 0,5 11 ± 0,2 98 ± 40 1316 ± 255*
100 5,8 ± 0,7* 13 ± 0,9 72 ± 38 1135 ± 300
50 8 ± 3,3 12 ± 0,2* 63 ± 14* 1095 ± 301
10 8 ± 3 19 ± 2 43 ± 16 894 ± 100