Table 1 Comparison of sampling techniques for different coagulation parameters: Vena cava puncture (VCP) vs tail cut (TC) as measured by Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT) in plasma of untreated negative control mice
From: Systemic coagulation parameters in mice after treatment with vascular targeting agents
Assay: | PT mean (SD) | aPTT mean (SD) | number of samples not evaluable | number of samples analyzed | % of samples not evaluable | |
|---|---|---|---|---|---|---|
Sampling technique: | [s] | [% of standard]* | [s] | [n] | [n] | [%] |
VCP 1:5 | 9.2 (1.0) | 94 (10) | 31.7 (4.6) | 3 | 15 | 20% |
VCP 1:10 | 7.8 (0.1) | 116 (13) | 23.2 (0.8) | 0 | 10 | 0% |
TC 1:5 | - | - | - | 3 | 3 | 100 % |
TC 1:10 | - | - | - | 4 | 4 | 100 % |
Ref.values: | 8–10 | 80–120 | 32–36/23–25†|  |  |  |