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Table 2 Comparison of sampling techniques for different coagulation parameters: Vena cava puncture (VCP) vs heart puncture (HP) as measured by Soluble Fibrin in plasma of untreated negative control mice

From: Systemic coagulation parameters in mice after treatment with vascular targeting agents

  Number of mice negative Number of mice with borderline result Number of mice positive Number of mice analyzed Number of positive results in negative control mice
sampling technique: n n n n %
VCP 1:5 17 1 0 18 0 %
VCP 1:10 10 2 5 17 29%
HP 1:5 0 0 5 5 100%
HP 1:10 3 0 10 13 77%
Ref.values: neg‡     
  1. ‡ negative, if no further manipulations are performed. If reagents are administered i.v., there can be up to 30% positive samples, independent of the reagent applied (see Fig. 2).