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Table 2 Comparison of sampling techniques for different coagulation parameters: Vena cava puncture (VCP) vs heart puncture (HP) as measured by Soluble Fibrin in plasma of untreated negative control mice

From: Systemic coagulation parameters in mice after treatment with vascular targeting agents

 

Number of mice negative

Number of mice with borderline result

Number of mice positive

Number of mice analyzed

Number of positive results in negative control mice

sampling technique:

n

n

n

n

%

VCP 1:5

17

1

0

18

0 %

VCP 1:10

10

2

5

17

29%

HP 1:5

0

0

5

5

100%

HP 1:10

3

0

10

13

77%

Ref.values:

neg‡

    
  1. ‡ negative, if no further manipulations are performed. If reagents are administered i.v., there can be up to 30% positive samples, independent of the reagent applied (see Fig. 2).