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Figure 10 | Thrombosis Journal

Figure 10

From: Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis

Figure 10

Schematic diagram summarizing the proposed mechanism of sFn mediated inhibition of monocyte adherence (and consequently cytotoxicity) to tumor cells. A. αLβ2 (orange) binds preferentially compared with αMβ2 (blue) to tumor cell CD54. B. Pre-treatment of tumor cells with sFn inhibits αLβ2 (αLβ2 does not bind fibrin(ogen) binding, but enhances αMβ2 mediated adherence). C. Pre-treatment of monocytes with sFn (sFn binds to αMβ2) allows adherence by both αLβ2 and sFn bound αMβ2 to tumor cell CD54. D. Pre-incubation of monocytes and tumor cells with sFn inhibits both αLβ2 and αMβ2 binding to sFn coated CD54.

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