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Table 1 Activating effect of agonists on Lag Time.

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus

Lag Time (minutes) mean ± SD

 

B

C

D

E

F

G

H

 

Saline

rFVIIa 5 μg/mL

p value B vs C

rFVIIa 2.6 μg/mL

P value B vs E

rFVIIa 0.5 μg/mL

p value B vs G

1. Saline

17.1 ± 5.1

7.9 ± 2.1

<0.001

8.2 ± 2.4

<0.001

9.0 ± 1.9

<0.001

2. ADP 2 μM

11.5 ± 3.0

7.2 ± 2.0

<0.001

7.6 ± 1.6

<0.001

8.1 ± 2.0

<0.001

3. Col 0.5 μg/mL

11.9 ± 3.1

7.0 ± 2.8

<0.001

7.9 ± 2.8

<0.001

8.4 ± 2.9

<0.001

4. AA 0.625 mmol/L

8.4 ± 2.0

5.9 ± 1.2

<0.05

6.2 ± 1.3

<0.05

6.8 ± 1.3

<0.05

5. AA 0.125 mmol/L

9.5 ± 2.7

6.5 ± 1.5

<0.05

7.0 ± 1.8

<0.05

7.3 ± 1.7

<0.05

  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.01 Column C: 1 vs 4 and 5 p < 0.01; Column E. 1 vs 4 and 5 p < 0.005 for both; Column G. 1 vs 4 and 5 p < 0.01 for both.
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Thrombosis Journal

ISSN: 1477-9560

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