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Table 1 Activating effect of agonists on Lag Time.

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus Lag Time (minutes) mean ± SD
  B C D E F G H
  Saline rFVIIa 5 μg/mL p value B vs C rFVIIa 2.6 μg/mL P value B vs E rFVIIa 0.5 μg/mL p value B vs G
1. Saline 17.1 ± 5.1 7.9 ± 2.1 <0.001 8.2 ± 2.4 <0.001 9.0 ± 1.9 <0.001
2. ADP 2 μM 11.5 ± 3.0 7.2 ± 2.0 <0.001 7.6 ± 1.6 <0.001 8.1 ± 2.0 <0.001
3. Col 0.5 μg/mL 11.9 ± 3.1 7.0 ± 2.8 <0.001 7.9 ± 2.8 <0.001 8.4 ± 2.9 <0.001
4. AA 0.625 mmol/L 8.4 ± 2.0 5.9 ± 1.2 <0.05 6.2 ± 1.3 <0.05 6.8 ± 1.3 <0.05
5. AA 0.125 mmol/L 9.5 ± 2.7 6.5 ± 1.5 <0.05 7.0 ± 1.8 <0.05 7.3 ± 1.7 <0.05
  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.01 Column C: 1 vs 4 and 5 p < 0.01; Column E. 1 vs 4 and 5 p < 0.005 for both; Column G. 1 vs 4 and 5 p < 0.01 for both.