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Table 3 Activating effect of agonists on Peak of TG (PTG).

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus

PTG (nmol/L) mean ± SD

 

B

C

D

E

F

G

H

 

Saline

rFVIIa 5 μg/mL

p value B vs C

rFVIIa 2.6 μg/mL

P value B vs E

rFVIIa 0.5 μg/mL

P value B vs G

1. Saline

97 ± 36

160 ± 36

<0.001

151 ± 42

<0.001

189 ± 42

<0.001

2. ADP 2 μM

156 ± 50

178 ± 49

NS

167 ± 45

NS

214 ± 70

<0.01

3. Col 0.5 μg/mL

158 ± 60

180 ± 45

NS

174 ± 46

NS

215 ± 63

<0.01

4. AA 0.625 mmol/L

160 ± 43

164 ± 42

NS

172 ± 49

NS

204 ± 59

<0.01

5. AA 0.125 mmol/L

191 ± 52

193 ± 52

NS

184 ± 49

NS

222 ± 69

NS

  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.001 for all Column C 1 vs 5 p < 0.01, Column E: 1 vs 5 p < 0.05
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Thrombosis Journal

ISSN: 1477-9560

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