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Table 3 Activating effect of agonists on Peak of TG (PTG).

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus PTG (nmol/L) mean ± SD
  B C D E F G H
  Saline rFVIIa 5 μg/mL p value B vs C rFVIIa 2.6 μg/mL P value B vs E rFVIIa 0.5 μg/mL P value B vs G
1. Saline 97 ± 36 160 ± 36 <0.001 151 ± 42 <0.001 189 ± 42 <0.001
2. ADP 2 μM 156 ± 50 178 ± 49 NS 167 ± 45 NS 214 ± 70 <0.01
3. Col 0.5 μg/mL 158 ± 60 180 ± 45 NS 174 ± 46 NS 215 ± 63 <0.01
4. AA 0.625 mmol/L 160 ± 43 164 ± 42 NS 172 ± 49 NS 204 ± 59 <0.01
5. AA 0.125 mmol/L 191 ± 52 193 ± 52 NS 184 ± 49 NS 222 ± 69 NS
  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.001 for all Column C 1 vs 5 p < 0.01, Column E: 1 vs 5 p < 0.05