|
B
|
C
|
D
|
E
|
---|
|
Lag Time (min.) mean ± SD
|
Time to Peak (min.) mean ± SD
|
PTG (nmol/L) mean ± SD
|
AUC (nmol/L) mean ± SD
|
---|
1 ADP
|
15.4 ± 4.0
|
23.2 ± 4.9
|
155 ± 41
|
1260 ± 474
|
2. AA +ADP
|
11.3 ± 2.5
|
17.3 ± 2.6
|
198 ± 45
|
1604 ± 188
|
3. Col
|
14.3 ± 3.3
|
21.6 ± 3.7
|
148 ± 44
|
1392 ± 264
|
4. AA+Col
|
11.8 ± 2.5
|
17.8 ± 3.3
|
187 ± 53
|
1551 ± 257
|
5. AA
|
12.9 ± 3.1
|
19.0 ± 3.4
|
179 ± 58
|
1488 ± 286
|
6. rTF
|
5.8 ± 1.8
|
12.9 ± 2.4
|
154 ± 50
|
1495 ± 337
|
- Parameters of TG in PRP from 30 normal volunteers. PTG: Peak to thrombin generation. AUC: Area under the curve. AA, ADP or Col were compared with their combining effects. Also rTF, 2.5 pM was compared with the other agonists.
- Lag Time: 1 vs 2 <0.001; 3 vs 4 <0.01; 2 vs 5 = NS; 4 vs 5 = NS 6 vs 1 to 5 <0.001
- Time to Peak 1 vs 2 <0.001; 3 vs 4 <0.001; 2 vs 5 = NS; 4 vs 5 = NS 6 vs 1 to 5 <0.001
- PTG 1 vs 2 <0.001; 3 vs 4 <0.01; 2 vs 5 =NS; 4 vs 5 =NS 6 vs 1 to 5 =NS
- AUCo→35min 1 vs 2 <0.001; 3 vs 4 =NS; 2 vs 5 =NS; 4 vs 5 =NS 6 vs 1 to 5 =NS
- rTF appears as more effective than each agonist alone or their combination in shorten times parameters of TG, but effects are not different when amount parameters are considered.