Macroscopic organ involvement after induction of DIC in anesthetized piglets. At necropsy, scores of 0 to 4 were given based on number of organs (right or left kidney, heart and liver) with visible evidence of hemorrhage. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr). Data are expressed as mean ± SD (standard deviation). *P < 0.025, compared with supportive therapy alone.