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Table 7 Changes in platelet count of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Platelet Count ± SD (× 103/cu. mm)

P-Value*

Group

Basal

Follow-up

Δ

B vs.

C vs.

D vs.

A: Supportive care

532 ± 274

179 ± 192

-353 ± 268

0.105

0.392

0.332

B: AT

574 ± 133

357 ± 134

-217 ± 79

 

0.090

0.775

C: R-TPA

543 ± 74

207 ± 85

-336 ± 130

  

0.407

D: AT + R-TPA

666 ± 203

408 ± 274

-258 ± 262

   
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for platelet count (paired t-test).
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Thrombosis Journal

ISSN: 1477-9560

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