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Table 7 Changes in platelet count of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Platelet Count ± SD (× 103/cu. mm) P-Value*
Group Basal Follow-up Δ B vs. C vs. D vs.
A: Supportive care 532 ± 274 179 ± 192 -353 ± 268 0.105 0.392 0.332
B: AT 574 ± 133 357 ± 134 -217 ± 79   0.090 0.775
C: R-TPA 543 ± 74 207 ± 85 -336 ± 130    0.407
D: AT + R-TPA 666 ± 203 408 ± 274 -258 ± 262    
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for platelet count (paired t-test).