Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Table 8 Changes in fibrinogen levels of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

Mean Fibrinogen Level ± SD (mg/dl)				P-Value*
Group	Basal	Follow-up	Δ	B vs.	C vs.	D vs.
A: Supportive care	144 ± 23	67 ± 27	-77 ± 34	0.102	0.786	0.571
B: AT	156 ± 26	104 ± 32	-52 ± 33		0.055	0.823
C: R-TPA	149 ± 31	60 ± 43	-89 ± 26			0.307
D: AT + R-TPA	157 ± 36	85 ± 33	-72 ± 52

Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for fibrinogen level (paired t-test).

ISSN: 1477-9560