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Table 8 Changes in fibrinogen levels of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Fibrinogen Level ± SD (mg/dl) P-Value*
Group Basal Follow-up Δ B vs. C vs. D vs.
A: Supportive care 144 ± 23 67 ± 27 -77 ± 34 0.102 0.786 0.571
B: AT 156 ± 26 104 ± 32 -52 ± 33   0.055 0.823
C: R-TPA 149 ± 31 60 ± 43 -89 ± 26    0.307
D: AT + R-TPA 157 ± 36 85 ± 33 -72 ± 52    
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for fibrinogen level (paired t-test).