Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study

Table 2 Proinflammatory SNPs stratified by race and case/control status demonstrating allelic variants, genotype call rate, minor allele frequencies and p-values for age-adjusted additive model and risk factor adjusted additive model.

Gene	SNP rs number, location and function	Alleles*	Call Rate (%)	African-Americans				Caucasians
				Cases	Controls	p-value		Cases	Controls	p-value
				Minor Allele Frequency/N	Minor Allele Frequency/N	Age-adjusted	Risk factor adjusted**	Minor Allele Frequency/N	Minor Allele Frequency/N	Age-adjusted	Risk factor adjusted**
CD14 ^ψ	rs2569190, 5' promotor	C/T	99%	0.38/77	0.42/62	0.57	0.66	0.49/65	0.40/75	0.13	0.30
IL1A	rs17561, exon 4 nonsynonymous	G/T	98%	0.18/102	0.18/90	0.83	0.73	0.27/93	0.31/94	0.32	0.80
IL1R1	rs3917318, intron 10	A/G	91%	0.33/97	0.29/88	0.44	0.23	0.33/92	0.36/92	0.53	0.24
ILIB	rs3917365, 3' near gene	C/T	81%	0.21/97	0.17/83	0.34	0.36	0.08/86	0.08/89	0.85	0.87
IL6	rs1800797, 5' near gene	A/G	91%	0.06/99	0.10/88	0.19	0.18	0.42/93	0.43/91	0.89	0.87
	rs2069830, exon 2 nonsynonymous	C/T	91%	0.07/100	0.09/87	0.32	0.31	0.01/90	0.03/93	0.30	0.35
	rs2069832, intron 2	C/T	89%	0.05/97	0.12/86	0.049	0.05	0.45/92	0.45/91	0.97	0.85
MMP3	rs679620, exon 2 nonsynonymous	C/T	89%	0.35/103	0.35/88	0.95	0.72	0.45/90	0.47/96	0.85	1.0

^ψCD14 SNP rs2569190 was genotyped in a smaller case-control sample (N = 315).
* Minor allele in African-Americans (bolded in column 3 above).
** Risk factor adjusted – Additive model adjusted for age, hypertension, diabetes, oral contraceptive use, and angina-MI.

ISSN: 1477-9560