Figure 1

In Vitro anticoagulant response in rat plasma produced by plasma purified proteins. Increasing concentrations of bAPC or hAPC, with or without PS (10 μg/ml), in rat (A+C) or human plasma (B+D) measured with either the APTT reagent Platelin LS (A+B) or with the tissue-factor reagent Simplastin Excel (C+D). Mean values and standard deviation (error bars) are presented. The indicated concentrations of APC refer to the concentrations of the proteins in the APC-containing solutions that were used to initiate the clotting reactions, as detailed in the Methods section. The experiments with bAPC in rat plasma, with or without bPS, were presented in one of our previous studies [19] and the same results are presented here again in the same figure as the experiments with hAPC, with or without hPS, in both plasma types to make comparisons possible.