Table 2 Multiple regression analysis of mean weekly warfarin dose (mg) related to genotypes, treatment group and age. Coefficients and significance levels are listed for each predictor. R2 values indicate the cumulative contribution of each predictor as they are entered into the model. P-value for the model was <0.0001.
Predictor | Warfarin dose (mg) | Significance | Adjusted R2(cumulative) |
|---|---|---|---|
Constant | 72.297 | P < 0.001 | |
VKORC1 1173 T/T | -18.946 | P < 0.001 | 0.101 |
VKORC1 1173 C/T | -11.930 | P < 0.001 | 0.245 |
Treatment group | -8.540 | P < 0.001 | 0.358 |
CYP2C9 *1/*2,*3 | -7.275 | P = 0.001 | 0.398 |
CYP2C9 *2/*2,*3 | -15.459 | P = 0.001 | 0.430 |
Age | -0.321 | P = 0.004 | 0.472 |