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Table 2 Multiple regression analysis of mean weekly warfarin dose (mg) related to genotypes, treatment group and age. Coefficients and significance levels are listed for each predictor. R2 values indicate the cumulative contribution of each predictor as they are entered into the model. P-value for the model was <0.0001.

From: Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction

Predictor Warfarin dose (mg) Significance Adjusted R2(cumulative)
Constant 72.297 P < 0.001  
VKORC1 1173 T/T -18.946 P < 0.001 0.101
VKORC1 1173 C/T -11.930 P < 0.001 0.245
Treatment group -8.540 P < 0.001 0.358
CYP2C9 *1/*2,*3 -7.275 P = 0.001 0.398
CYP2C9 *2/*2,*3 -15.459 P = 0.001 0.430
Age -0.321 P = 0.004 0.472
  1. Dose [mg/week] = 72.297 - 18.946 · (T/T) -11.930· (C/T) - 8.540 · (group) -7.275 · (*1/*2,*3) - 15.459 · (*2/*2,*3) - 0.321· (age)