Figure 5
Flow cytometry study in which phosphorylation of VASP (and hence inhibition of platelet activation) is stimulated by PGE 1 and dephosphorylation (and hence augmentation of platelet activation) is mediated by ADP. Platelet activation is represented as platelet reactivity index (%PRI). ADP-stimulated platelet aggregation at baseline [a], after pretreatment with clopidogrel po [b], and after pretreatment with AZD6140 (10 μM) ex vivo [c]. n = 8. Filled symbols represents normothermia (37°), open symbols represents hypothermia (33°), n.s. = not significant.