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Figure 1 | Thrombosis Journal

Figure 1

From: Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

Figure 1

A) MRL-677 added to murine whole blood at the concentrations indicated inhibited the binding of mCCR2 on PBMCs . Each point represents the average of three measurements and the error bars represent the standard error of the mean. The potency (IC50) of the compound was determined to be 3.2 nM (+ 0.1 SE) and was determined by a four parameter fit of the data as shown. B) MRL-677 given orally inhibits recruitment of monocytes into the peritoneal cavity. The number of monocytes recruited to the peritoneal cavity was quantitated by F4/80 staining of the cellular exudate on day 3 post-intraperitoneal thioglycollate administration. Oral administration of MRL-677 for the three days at the doses indicated was able to inhibit monocyte recruitment to the peritoneal cavity.

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