Table 1 CCR2 Antagonist MRL-677 Competition
From: Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation
| Â | IC50or % inhibition |
|---|---|
Murine CCR2 | 1.8 ± 0.4 nM |
Murine CCR5 | 418 ± 76 nM |
Human CCR1 | 24% @ 10 μM |
Human CCR3 | No inhibition @ 1 μM |
Human CCR8 | No inhibition @ 1 μM |
Human CXCR1 | 8% @ 10 μM |
Human CXCR2 | 11% @ 1 μM |
Human CXCR3 | 3% @ 1 μM |