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Table 1 CCR2 Antagonist MRL-677 Competition

From: Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation

  IC50or % inhibition
Murine CCR2 1.8 ± 0.4 nM
Murine CCR5 418 ± 76 nM
Human CCR1 24% @ 10 μM
Human CCR3 No inhibition @ 1 μM
Human CCR8 No inhibition @ 1 μM
Human CXCR1 8% @ 10 μM
Human CXCR2 11% @ 1 μM
Human CXCR3 3% @ 1 μM