Table 1 Characteristics for the 3 study groups (control, moderate and severe periodontitis).
Control (n = 24) | Moderate Periodontitis (n = 38) | Severe Periodontitis (n = 30) | p-value1 | |
|---|---|---|---|---|
Age (years) | 38.4 ± 11.3 | 43.8. ± 8.7 | 45.5 ± 7.7 | 0.017 |
Gender | NS | |||
Male | 7 (29%) | 16 (42%) | 13 (43%) | |
Female | 17 (71%) | 22 (58%) | 17 (57%) | |
Ethnicity | ||||
Caucasian | 21 (88%) | 29 (76%) | 26 (87%) | NS |
Other | 3 (12%) | 9 (24%) | 4 (13%) | |
Education level | 0.019 | |||
<High school | 6 (25%) | 25 (65%) | 14 (47%) | |
=High school | 7 (29%) | 2 (5%) | 5 (16%) | |
>High school | 11 (46%) | 11 (29%) | 11 (37%) | |
Smoking habits | NS | |||
Smoker | 7 (29%) | 19 (50%) | 14 (47%) | |
Non-smoker | 17 (71%) | 19 (50%) | 16 (53%) | |
BMI (kg/m2) | 24.6 ± 3.9 | 26.1 ± 5.5 | 23.9 ± 2.7 | NS |
Total Cholesterol (mmol/l) | 5.2 ± 1.1 | 5.4 ± 1.2 | 5.5 ± 1.1 | NS |
HDL/Chol. (mmol/l) | 1.5 ± 0.4 | 1.3 ± 0.4 | 1.4 ± 0.4 | NS |
LDL/Chol. (mmol/l) | 3.1 ± 1.0 | 3.4 ± 1.1 | 3.6 ± 1.0 | NS |
Triglycerides (mmol/l) | 1.2 ± 0.6 | 1.5 ± 0.8 | 1.3 ± 0.7 | NS |
Total number of teeth | 28.3 ± 2.3 | 26.0 ± 3.9 | 25.7 ± 3.2 | 0.010 |
Teeth ≥30% bone loss | 0.0 ± 0.0 | 14.2 ± 5.9 | 21.0 ± 3.5 | NT |
Teeth ≥50% bone loss | 0.0 ± 0.0 | 2.5 ± 1.6 | 11.0 ± 4.5 | NT |
hsCRP (mg/l) | 1.40 (0.42-4.0) | 2.18 (0.92-5.13) | 1.43 (0.87-3.13) | NS |
Prothrombotic state | ||||
vWF (%) | 75.0 (63.0-98.5) | 92.5 (75.0-111.0) | 90.5 (72.7-108.5) | NS |
F 1+2 (nmol/l) | 0.84 (0.64-1.08) | 1.02 (0.82-1.30) | 1.01 (0.72-1.36) | NS |
PAI-1 (AU/ml) | 0.30 (0.20-6.42) | 4.32 (0.20-13.60 | 11.45 (1.47-27.18) | 0.009 |
D-dimer (ng/ml) | 31.0 (13.0-68.0) | 25.5 (10.5-46.5) | 16.0 (1.75-47.2) | NS |
Serum antibodies | ||||
Anti-Aa IgG | 0.41 (0.36-0.63) | 0.82 (0.45-1.52) | 0.85 (0.39-1.58) | 0.015 |
Anti-Pg IgG | 0.60 (0.49-0.82) | 0.66 (0.42-1.07) | 0.70 (0.46-1.48) | NS |