Figure 3

Effect of blocking antibodies against the major leukocyte integrins on fibrinogen-triggered pro-coagulant activation of human monocytes. Pre-treatment of human monocytes in the additional presence of blocking antibodies against Mac-1 or LFA-1 led to a sustainable prolongation of the coagulation time compared to fibrinogen- or digestion fragment D-treated cells alone; antibodies in the absence of fibrinogen or fibrinogen fragment D did not alter coagulation times (data not shown). Experiments were performed with the intact fibrinogen molecule. Results are given as mean ± SEM, n = 3. Control: p < 0.05.