Figure 5

Inhibition of MMP-9 decreases the fibrinogen-triggered pro-coagulant activation of human monocytes. Monocytes were pre-treated with specific inhibitors of matrix metalloproteases (MMP)-1, -3, -8, -9 and -13, and exposed to fibrinogen. Then coagulation experiments were performed. The inhibitor of MMP-9 increased the time to clot formation to 355 ± 23.4 sec which was about the same for un-treated cells. Other MMP inhibitors did not interfere with fibrinogen-initiated clot formation. Results are given as mean ± SEM, n = 3. MMP-9: p < 0.05.