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Table 1 Lung inflammation measurements

From: Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats

Parameter

Time

Sprague-Dawley

Copenhagen

  

PE

Sham

Sig.

PE

Sham

Sig

Weight (g)

24 hr

399 ± 5

392 ± 4

n.s.

240 ± 8

254 ± 2

n.s.

 

5 day

402 ± 5

393 ± 5

n.s.

244 ± 8

245 ± 4

n.s.

Pleural WBC (×105)

24 hr

108 ± 19

109 ± 32

n.s.

27 ± 4

32 ± 4

n.s.

 

5 day

107 ± 16

109 ± 4

n.s.

39 ± 8

31 ± 3

n.s.

BAL WBC (×103)

24 hr

543 ± 45

337 ± 35

*

491 ± 26

415 ± 51

n.s.

 

5 day

587 ± 82

514 ± 40

n.s.

449 ± 65

435 ± 44

n.s.

BAL Chemotaxis (×103)

24 hr

52 ± 9

33 ± 3

n.s.

16 ± 1

17 ± 2

n.s.

 

5 day

41 ± 4

37 ± 4

n.s.

18 ± 2

13 ± 5

n.s.

BAL MPO (U/mL)

24 hr

229 ± 79

104 ± 23

n.s.

128 ± 11

152 ± 57

n.s.

 

5 day

256 ± 133

301 ± 65

n.s.

142 ± 87

102 ± 19

n.s.

BAL MCP-1 (pg/mL)

24 hr

137 ± 90

42 ± 14

n.s.

188 ± 112

134 ± 48

n.s.

 

5 day

24 ± 13

101 ± 80

n.s.

187 ± 105

228 ± 59

n.s.

BAL CINC-1 (pg/mL)

24 hr

62 ± 32

32 ± 11

n.s.

66 ± 14

38 ± 12

n.s.

 

5 day

21 ± 6

30 ± 12

n.s.

36 ± 8

41 ± 7

n.s.

BAL CINC-2 (pg/mL)

24 hr

638 ± 51

554 ± 32

n.s.

267 ± 23

220 ± 28

n.s.

 

5 day

610 ± 45

552 ± 40

n.s.

266 ± 42

280 ± 18

n.s.

BAL CINC-3 (pg/mL)

24 hr

21 ± 1

21 ± 0.4

n.s.

19 ± 4

19 ± 8

n.s.

 

5 day

20 ± 0.3

20 ± 0.1

n.s.

18 ± 6

15 ± 4

n.s.

  1. Values are mean ± standard error, where n = 10 Sprague-Dawley, n = 4-5 Copenhagen. *Indicates a value significantly different from vehicle-treated Sham animals (Bonferroni-adjusted p < 0.05, t-Test). Abbreviations: not significant (n.s.); pleural white blood cell count (WBC); bronchoalveolar lavage fluid (BAL); white blood cell count (WBC); in vitro neutrophil chemotaxis in response to BAL fluid (Chemotaxis) myeloperoxidase activity (MPO); monocyte chemotactic factor (MCP); cytokine-induced neutrophil chemotactic factor (CINC).