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Table 2 Frequency of the TF and TFPI polymorphisms in CHD patients and healthy controls

From: Gender differences of polymorphisms in the TF and TFPI genes, as related to phenotypes in patients with coronary heart disease and type-2 diabetes

Genotype

CHD n (%)

Controls n (%)

p

TF -1812

 

996

 

204

 

CC

327

(32.8)

63

(30.9)

 

CT

466

(46.8)

102

(50.0)

>0.2

TT

203

(20.4)

39

(19.1)

 

Allele T frequency

0.438

 

0.441

  

TF -603

 

996

 

204

 

AA

326

(32.7)

63

(30.9)

 

AG

466

(46.8)

102

(50.0)

> 0.2

GG

204

(20.5)

39

(19.1)

 

Allele G frequency

0.439

 

0.441

  

TF 5466

 

996

 

204

 

AA

879

(88.3)

181

(88.7)

 

AG

112

(11.3)

22 )

(10.8

> 0.2

GG

5

(0,5)

1

(0.5)

 

Allele G frequency

0.061

 

0.059

  

TFPI-399

 

996

 

204

 

CC

758

(76.1)

158

(77.5)

 

CT

224

(22.5)

41

(20.1)

> 0.2

TT

14

(1.4)

5

(2.5)

 

Allele T frequency

0.127

 

0.125

  

TFPI -287

996

  

204

 

TT

723

(72.6)

148

(72.6)

 

TC

245

(24.6)

55

(27.0)

> 0.2

CC

28

(2.8)

1

(0.5)

 

Allele C frequency

0.151

 

0.140

  

TFPI -33

 

996

 

203*

 

TT

512

(51.4)

102

(50.3)

 

TC

405

(40.7)

87

(42.9)

> 0.2

CC

79

(7.9)

14

(6.9)

 

Allele C frequency

0.283

 

0.283

  

Haplotypes

     

TF I

65

(6.5)

13

(6.4)

> 0.2

  1. Calculations are performed with comparison of the heterozygous and homozygous pooled,
  2. versus the wild type.
  3. Haplotypes: TFI is the combination of TF -1812 CC and TF 5466 AG/GG
  4. p-values refer to differences between CHD patients and controls.
  5. *The TFPI -33 polymorphism was detectable in 203 out of 204 controls.
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Thrombosis Journal

ISSN: 1477-9560

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