Skip to main content

Advertisement

Table 3 Association between TF and TFPI polymorphisms in subgroups of the CHD population

From: Gender differences of polymorphisms in the TF and TFPI genes, as related to phenotypes in patients with coronary heart disease and type-2 diabetes

Genotype No with T2DM+/- % with T2DM p-value No of Male/Female % Female p-value
TF -1812       
CC 71/256 22   246/81 25  
CT 93/373 20 >0.2 366/100 21 0.124
TT 35/168 17   166/37 18  
TF -603       
AA 71/255 22   245/81 25  
AG 93/373 20 >0.2 366/100 21 0.115
GG 35/169 17   167/37 18  
TF 5466       
AA 179/700 20   703/176 20  
AG 19/93 17 >0.2 72/40 36 <0.001
GG 1/4 20   3/2 40  
TFPI -399       
CC 151/607 20   602/156 21  
CT 45/179 20 >0.2 166/58 26 0.075
TT 3/11 21   10/4 29  
TFPI -287       
TT 145/578 20   564/159 22  
TC 49/196 20 >0.2 194/51 21 >0.2
CC 5/23 18   20/8 29  
TFPI -33       
TT 97/415 19   399/113 22  
TC 87/318 22 >0.2 315/90 22 >0.2
CC 15/64 19   64/15 19  
Haplotypes       
TF I 13/35 20 >0.2 39/26 40 <0.001
  1. Calculations are performed with comparison of the heterozygous and homozygous pooled, versus the wild type.
  2. Haplotypes: TFI is the combination of TF -1812 CC and TF 5466 AG/GG
  3. p-values refer to differences between disease states and gender, as related to genotype.