Gender differences of polymorphisms in the TF and TFPI genes, as related to phenotypes in patients with coronary heart disease and type-2 diabetes

Table 3 Association between TF and TFPI polymorphisms in subgroups of the CHD population

Genotype	No with T2DM+/-	% with T2DM	p-value	No of Male/Female	% Female	p-value
TF -1812
CC	71/256	22		246/81	25
CT	93/373	20	>0.2	366/100	21	0.124
TT	35/168	17		166/37	18
TF -603
AA	71/255	22		245/81	25
AG	93/373	20	>0.2	366/100	21	0.115
GG	35/169	17		167/37	18
TF 5466
AA	179/700	20		703/176	20
AG	19/93	17	>0.2	72/40	36	<0.001
GG	1/4	20		3/2	40
TFPI -399
CC	151/607	20		602/156	21
CT	45/179	20	>0.2	166/58	26	0.075
TT	3/11	21		10/4	29
TFPI -287
TT	145/578	20		564/159	22
TC	49/196	20	>0.2	194/51	21	>0.2
CC	5/23	18		20/8	29
TFPI -33
TT	97/415	19		399/113	22
TC	87/318	22	>0.2	315/90	22	>0.2
CC	15/64	19		64/15	19
Haplotypes
TF I	13/35	20	>0.2	39/26	40	<0.001

Calculations are performed with comparison of the heterozygous and homozygous pooled, versus the wild type.
Haplotypes: TFI is the combination of TF -1812 CC and TF 5466 AG/GG
p-values refer to differences between disease states and gender, as related to genotype.

ISSN: 1477-9560