Effect on the lag time and time to peak thrombin generation with different concentrations of recombinant factor VIIa (5 μg/μL down to 0.125 μg/μL). Results are expressed as the mean values of samples obtained from 29 volunteers. Arrows indicate a statistical difference between values. Saline vs all rFVIIa concentrations, p < 0.001 (one-way ANOVA). * Differences between different concentrations of rFVIIa. Post-hoc comparison.