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Table 1 Activating effect of different concentrations of tissue factor (TF), alone or combined with different concentrations of recombinant activated factor VII (rFVIIa), on thrombin generation (TG) parameters in normal platelet-poor plasma (PPP)

From: The hemostatic profile of recombinant activated factor VII. Can low concentrations stop bleeding in off-label indications?

  Column B Saline Column C. rFVIIa 5.0 μg/mL Column D. rFVIIa 2.5 μg/mL Column E. rFVIIa 0.5 μg/mL Column B vs C vs D vs E Column C vs D/C vs E
Lag time (min, mean ± SD)
TF 5.0 pM 3.2 ± 0.7 2.1 ± 0.4 2.1 ± 0.4 2.1 ± 0.4 <0.001 0.999/0.999
TF 2.5 pM 4.2 ± 1.2 2.9 ± 0.7 3.0 ± 0.6 3.0 ± 0.6 <0.001 0.686/0.686
TF 1.25 pM 6.0 ± 1.4 3.7 ± 0.9 3.6 ± 0.9 4.1 ± 0.7 <0.001 0.744/0.196
TF 0.5 pM 8.1 ± 1.8 5.3 ± 1.1 5.1 ± 1.2 5.7 ± 1.2 <0.001 0.627/0.332
P-value (one-way ANOVA) <0.001 <0.001 <0.001 <0.001   
Peak of TG (nmol/l, mean ± SD)
TF 5.0 pM 389 ± 105 367 ± 86 385 ± 84 400 ± 75 0.661  
TF 2.5 pM 278 ± 105 269 ± 87 269 ± 86 290 ± 79 0.746  
TF 1.25 pM 178 ± 97 214 ± 90 217 ± 94 214 ± 75 0.421  
TF 0.5 pM 123 ± 91 146 ± 101 145 ± 99 169 ± 99 0.489  
P-value (one-way ANOVA) <0.001 <0.001 <0.001 <0.001   
AUC (nmol/l, mean ± SD)
TF 5.0 pM 2094 ± 425 2389 ± 435 2337 ± 431 2454 ± 387 0.032 0.907/0.611
TF 2.5 pM 1875 ± 431 2137 ± 431 2030 ± 423 2244 ± 403 0.033 0.499/0.405
TF 1.25 pM 1427 ± 466 1944 ± 477 1824 ± 456 1904 ± 437 0.001 0.391/0.922
TF 0.5 pM 1115 ± 507 1512 ± 664 1426 ± 561 1659 ± 613 0.023 0.552/0.412
P-value (one-way ANOVA) <0.001 <0.001 <0.001 <0.001   
  1. ANOVA = analysis of variance