Table 3 Proportion of cases and controls with risk factors for extreme dose variability (unadjusted results).
From: Using highly variable warfarin dosing to identify patients at risk for adverse events
Risk Factors | Cases (n = 109) | Controls (n = 218) | p-value* |
|---|---|---|---|
Acetaminophen | 33 (30%) | 30 (14%) | < 0.001 |
Adherence | 48 (44%) | 67 (31%) | 0.01 |
Alcohol | 9 (8%) | 16 (7%) | 0.99 |
Alternative Medication | 11 (10%) | 10 (5%) | 0.08 |
Amiodarone | 12 (11%) | 0 (0%) | < 0.001 |
Antibiotic Use | 47 (43%) | 44 (20%) | < 0.001 |
Cancer | 8 (7%) | 1 (0%) | < 0.001 |
CHF (Decompensated) | 14 (13%) | 7 (3%) | 0.001 |
Decreased Oral Intake | 21 (19%) | 8 (4%) | < 0.001 |
Diarrhea | 15 (14%) | 10 (5%) | 0.003 |
Dietary Supplement | 8 (7%) | 6 (3%) | 0.06 |
Dietary Vitamin K | 40 (37%) | 73 (34%) | 0.61 |
Hospitalizations/Nursing Home | 47 (43%) | 12 (6%) | < 0.001 |
Missed Appointments | 12 (11%) | 22 (10%) | 0.99 |
Nausea/Vomiting | 10 (9%) | 5 (2%) | 0.01 |
NSAID Use | 19 (17%) | 18 (8%) | 0.02 |
Procedures | 28 (26%) | 41 (19%) | 0.21 |
Systemic Steroids | 12 (11%) | 9 (4%) | 0.03 |