Indication/agent | Ref. | N | Dose | Comparator | VTE, % | Major bleeding, % |
---|---|---|---|---|---|---|
Hip replacement surgery | Â | Â | Â | Â | Â | |
   Enoxaparin | [19] | 100 | 30 mg bid | Placebo | 12 vs 42 (p = 0.0007) | 2 vs 4 |
 | [20] | 665 | 30 mg bid | UFH bid | 17.1 vs 19.0 | 3.3 vs 5.7 |
 | [21] | 607 | 40 mg once daily | UFH tid | 15 vs 12 | 1 vs 6 (p = 0.014) |
 |  |  | 30 mg bid |  | 5 vs 12 (p = 0.03) | 4 vs 6 |
 | [22] | 3,011 | 30 mg bid | Warfarin | 0.3 vs 1.1* (p = 0.0083) | 0.6 vs 0.3 |
   Dalteparin | [23] | 1,472 | 2,500 pre-op and post-op, 5,000 IU once daily | Warfarin | 10.7 vs 24 (p < 0.001) | 2.2 vs 0.4 (p = 0.01) |
 |  |  | 2,500 post-op, 5,000 IU once daily |  | 13.1 vs 24 (p < 0.001) | 0.8 vs 0.4 |
   Tinzaparin | [24] | 440 | 4,500 IU | Enoxaparin 40 mg once daily | 21.7 vs 20.1 | 0.9 vs 1.8 |
   Fondaparinux | [25] | 2,309 | 2.5 mg once daily | Enoxaparin 40 mg once daily | 4 vs 9 (p < 0.0001) | 4 vs 3 |
 | [26] | 1,584 | 2.5 mg once daily | Enoxaparin 30 mg bid | 6 vs 8 | 2.0 vs 0.7 |
Knee replacement surgery | Â | Â | Â | Â | Â | |
   Enoxaparin | [27] | 670 | 30 mg bid | Warfarin | 36.9 vs 51.7 (p = 0.003) | 2.1 vs 1.8 |
 | [28] | 349 | 30 mg bid | Warfarin | 25.4 vs 45.5 (p = 0.0001) | 5.2 vs 2.3 |
   Fondaparinux | [29] | 724 | 2.5 mg bid | Enoxaparin 30 mg bid | 12.5 vs 27.8 (p < 0.001) | 2.1 vs 0.2 (p = 0.006) |
Hip fracture surgery | Â | Â | Â | Â | Â | |
   Fondaparinux | [30] | 1,250 | 2.5 mg once daily | Enoxaparin 40 mg once daily | 8.3 vs 19.1 (p < 0.001) | 2.2 vs 2.3 |
Abdominal surgery | Â | Â | Â | Â | Â | |
   Enoxaparin | ENOXACAN [31] | 631 | 40 mg once daily | UFH tid | 14.7 vs 18.2 | 4.1 vs 2.9 |
   Dalteparin | [13] | 3,809 | 2,500 IU | UFH bid | 1.0 vs 1.1* | 3.6 vs 4.8 |
 | [32] | 1,957†| 5,000 IU | Dalteparin 2,500 IU | 6.6 vs 12.7 (p < 0.001) | 1.3 vs 0.3 |
   Fondaparinux | [33] | 2,048 | 2.5 mg once daily | Dalteparin 2,500 pre-op and post-op, 5,000 IU once daily | 4.6 vs 6.1 (p = 0.144) | 3.4 vs 2.4 (p = 0.122) |
Acutely ill medical inpatients | Â | Â | Â | Â | Â | |
   Enoxaparin | MEDENOX [34] | 866 | 40 mg once daily | Placebo | 5.5 vs 14.9 (p < 0.001) | 3.4 vs 2.0 |
 | [35] | 959 | 40 mg once daily | UFH tid | 0.2 vs 1.4* | 0.4 vs 1.5 |
 | [36] | 451 | 40 mg once daily | UFH tid | 8.4 vs 10.4 (p = 0.015 for equivalence) | 0.3 vs 0.3 |
 | [37] | 212 | 40 mg once daily | UFH 5,000 U tid | 19.7 vs 34.7 (p = 0.044) | 2.8 vs 1.9 |
 | [38] | 1,762 | 40 mg once daily | UFH 5,000 U bid | 10 vs 18 (p = 0.0001) | 1 vs 0 (p = 0.015) |
   Dalteparin | PREVENT [39] | 3,706 | 5,000 IU | Placebo | 2.77 vs 4.96 (p = 0.0015) | 0.49 vs 0.16 (p = 0.15) |
   Fondaparinux | ARTEMIS [40] | 849 | 2.5 mg once daily | Placebo | 5.6 vs 10.5 (p = 0.029) | 0.2 vs 0.2 |