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Figure 1 | Thrombosis Journal

Figure 1

From: Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis

Figure 1

Clinical course of index proband over 30 years. The initial presentation of cerebral thrombosis, thrombophlebitis and cerebrovascular accident (CVA) led to further investigations. The patient was found to have very elevated total homocysteine (tHcy) levels and Factor V Leiden. Treatment with warfarin and folate, vitamin B12 and vitamin B6 resulted in a dramatic reduction of tHcy. Over a 12-year follow-up period, no further thrombo-embolic phenomena were observed.

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Thrombosis Journal

ISSN: 1477-9560

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