Table 1 The reasons of hypercoagulation in different states associated with risk of thrombosis discussed in the article
From: Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk
Background state | Activating material | Increased level of procoagulant zymogens | Decreased level of coagulation inhibitors | Fibrinolysis abnormalities | Other hemostasis abnormalities | Type of thrombosis |
|---|---|---|---|---|---|---|
Cancer | ТF, NET, MP |  |  |  | Сancer procoagulant, adhesive molecules | Venous thrombosis |
Pregnancy | TF, МР| Fg, VII, VIII, X | Free protein S | PAI-1↑, PAI-2↑ | Thrombocytopenia, platelets activation, VWF↑ | Venous thrombosis, Arterial thrombosis |
Oral contraceptives |  | Fg, II, VII, VIII, X | ATIII, PS, TFPI | tPA↑, PAI-1↓ |  | Venous thrombosis |
Diabetes mellitus | TF, platelet, monocyte, endothelial МP | Fg, II, V, VII, VIII, and X | ATIII, PC, endothelial ТМ | PAI-1↑, tPA↑ | Enhanced platelet adhesion, aggregation, leukocyte activation, VWF↑ | Arterial thrombosis, Venous thrombosis? |