Table 2 Examples of АPPT ratio response to different procoagulant states
From: Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk
Procoagulant state | Number of patients in study group | Data range in control group, mean ± SD unless otherwise indicated | Data range in group with hypercoagulation, mean ± SD unless otherwise indicated | Significance | Predictive value | Reference | Comments |
|---|---|---|---|---|---|---|---|
VTE | 605 patients, 1290 - controls | Median(range) 1.00(0.72-1.33) | Median(range) 0.97(0.75-1.41) | <0.001 | APTT ratio < 0.87 OR = 2.4 | [52] | Retrospective study. |
Recurrence after first unprovoked VTE | 918 with a first VTE 101 – with recurrence | 0.97 ± 0.09 | 0.93 ± 0.09 | 0.001 | APTT ratio < 0.95 RR = 1.79 | [53] | Prospective study. Analysis was performed 3 weeks after after completion of anticoagulant therapy. |
Recurrence after first unprovoked VTE | 628 with a first VTE, 71 – with recurrence | APTT ratio < 0.90 RR = 2.38 compared with APTT ratio > 1.05 | [54] | Prospective study. Analysis wasperformed 3-4 weeks after after completion of anticoagulant therapy. | |||
Type 2 diabetes mellitus | 60 patients, 57 controls | Median(range) 0.93 (0.71–1.34) | Median(range) 1.03 (0.79–1.27) | 0.43 | [55] |