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Table 2 Examples of АPPT ratio response to different procoagulant states

From: Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk

Procoagulant state Number of patients in study group Data range in control group, mean ± SD unless otherwise indicated Data range in group with hypercoagulation, mean ± SD unless otherwise indicated Significance Predictive value Reference Comments
VTE 605 patients, 1290 - controls Median(range) 1.00(0.72-1.33) Median(range) 0.97(0.75-1.41) <0.001 APTT ratio < 0.87 OR = 2.4 [52] Retrospective study.
Recurrence after first unprovoked VTE 918 with a first VTE 101 – with recurrence 0.97 ± 0.09 0.93 ± 0.09 0.001 APTT ratio < 0.95 RR = 1.79 [53] Prospective study. Analysis was performed 3 weeks after after completion of anticoagulant therapy.
Recurrence after first unprovoked VTE 628 with a first VTE, 71 – with recurrence     APTT ratio < 0.90 RR = 2.38 compared with APTT ratio > 1.05 [54] Prospective study. Analysis wasperformed 3-4 weeks after after completion of anticoagulant therapy.
Type 2 diabetes mellitus 60 patients, 57 controls Median(range) 0.93 (0.71–1.34) Median(range) 1.03 (0.79–1.27) 0.43   [55]