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Table 1 SLE diagnostic criteria (modified from [1])
| Systemic lupus erythematosus: diagnostic criteria (2012 – SLICC) | |
|---|---|
| Cutaneous manifestation – 4 Items | Acute Cutaneous Lupus Erythematosus/Subacute Cutaneous Lupus Erythematosus |
| Chronic Cutaneous Lupus Erythematosus | |
| Oral ulcers | |
| Non-scarring alopecia | |
| Joints – 1 Item | Synovitis > 2 peripheral joints (pain, tenderness, swelling or morning stiffness > 30 min) |
| Serositis – 1 item | Pleuritis, typical pleurisy ≥ 1 day, history, rub, evidence of pleural effusion, pericarditis, typical pericardial pain ≥ 1 day, EKG evidence of pericardial fusion) |
| Renal disorder – 1 Item | Urine protein/creatinine ratio or urinary protein concentration of 0.5 g of protein/24 h, Red blood cell casts |
| Haematological disorder – 3 Items | Haemolytic anaemia |
| Leukopenia (<4000/mm3) or lymphopenia (<1000/mm3) separately at least once | |
| Thrombocytopenia (<100,000/mm3) at least once | |
| Immunologic abnormal – 6 Items | Positive ANA |
| Positive anti-dsDNA (except ELISA) on ≥ 2 occasions | |
| Anti-Sm | |
| Antiphospholipid antibody (including lupus anticoagulant, false-positive RPR, anti-cardiolipin, anti-beta2glycoprotein1) | |
| Low complement (C3, C4 or CH50) | |
| Direct Coombs test in the absence of haemolytic anaemia | |
| Diagnosis | Fulfil 4 items (at least one clinical and one immunologic item) |
