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Cutaneous manifestation – 4 Items
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Acute Cutaneous Lupus Erythematosus/Subacute Cutaneous Lupus Erythematosus
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Chronic Cutaneous Lupus Erythematosus
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Oral ulcers
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Non-scarring alopecia
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Joints – 1 Item
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Synovitis > 2 peripheral joints (pain, tenderness, swelling or morning stiffness > 30 min)
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Serositis – 1 item
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Pleuritis, typical pleurisy ≥ 1 day, history, rub, evidence of pleural effusion, pericarditis, typical pericardial pain ≥ 1 day, EKG evidence of pericardial fusion)
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Renal disorder – 1 Item
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Urine protein/creatinine ratio or urinary protein concentration of 0.5 g of protein/24 h, Red blood cell casts
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Haematological disorder – 3 Items
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Haemolytic anaemia
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Leukopenia (<4000/mm3) or lymphopenia (<1000/mm3) separately at least once
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Thrombocytopenia (<100,000/mm3) at least once
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Immunologic abnormal – 6 Items
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Positive ANA
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Positive anti-dsDNA (except ELISA) on ≥ 2 occasions
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Anti-Sm
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Antiphospholipid antibody (including lupus anticoagulant, false-positive RPR, anti-cardiolipin, anti-beta2glycoprotein1)
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Low complement (C3, C4 or CH50)
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Direct Coombs test in the absence of haemolytic anaemia
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Diagnosis
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Fulfil 4 items (at least one clinical and one immunologic item)
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