Table 1 SLE diagnostic criteria (modified from [1])
Systemic lupus erythematosus: diagnostic criteria (2012 – SLICC) | |
|---|---|
Cutaneous manifestation – 4 Items | Acute Cutaneous Lupus Erythematosus/Subacute Cutaneous Lupus Erythematosus |
Chronic Cutaneous Lupus Erythematosus | |
Oral ulcers | |
Non-scarring alopecia | |
Joints – 1 Item | Synovitis > 2 peripheral joints (pain, tenderness, swelling or morning stiffness > 30 min) |
Serositis – 1 item | Pleuritis, typical pleurisy ≥ 1 day, history, rub, evidence of pleural effusion, pericarditis, typical pericardial pain ≥ 1 day, EKG evidence of pericardial fusion) |
Renal disorder – 1 Item | Urine protein/creatinine ratio or urinary protein concentration of 0.5 g of protein/24 h, Red blood cell casts |
Haematological disorder – 3 Items | Haemolytic anaemia |
Leukopenia (<4000/mm3) or lymphopenia (<1000/mm3) separately at least once | |
Thrombocytopenia (<100,000/mm3) at least once | |
Immunologic abnormal – 6 Items | Positive ANA |
Positive anti-dsDNA (except ELISA) on ≥ 2 occasions | |
Anti-Sm | |
Antiphospholipid antibody (including lupus anticoagulant, false-positive RPR, anti-cardiolipin, anti-beta2glycoprotein1) | |
Low complement (C3, C4 or CH50) | |
Direct Coombs test in the absence of haemolytic anaemia | |
Diagnosis | Fulfil 4 items (at least one clinical and one immunologic item) |