Markers of thrombin generation are associated with myocardial necrosis and left ventricular impairment in patients with ST-elevation myocardial infarction

Thrombosis Journal

Table 4 Determinants of peak Troponin T (a) and NT-proBNP (b)

Determinants	Standardized beta	95 % CI^c	p-value	Determinants	Standardized beta	95 % CI	p-value
a)
D-dimer	0.138	<0.001– < 0.001	<0.001	F1 + 2	0.216	0.001–0.001	<0.001
Age	−0.054	−0.012–0.002	0.156	Age	−0.052	−0.012–0.002	0.157
Sex	0.025	−0.117–0.261	0.457	Sex	0.020	−0.128–0.244	0.542
BMI	−0.026	−0.025–0.012	0.466	BMI	−0.013	−0.22–0.015	0.706
HT	−0.006	−0.179–0.152	0.870	HT	−0.013	−0.194–0.132	0.710
Time frame^a	−0.076	−0.018– − 0.001	0.032	Time frame^a	−0.071	−0.017– < −0.001	0.042
CRP^b	0.081	0.031–0.333	0.018	CRP^b	0.083	0.039–0.335	0.013
NT-ProBNP	0.187	0.183–0.423	<0.001	NT-ProBNP	0.196	0.199–0.435	<0.001
b)
D-dimer	0.063	<−0.001– < 0.001	<0.001	F1 + 2	0.024	<−0.001– < 0.001	0.446
Age	0.180	0.011–0.023	0.050	Age	0.190	0.012–0.024	<0.001
Sex	−0.083	−0.405– − 0.061	<0.001	Sex	−0.085	−0.412– − 0.067	0.007
BMI	−0.086	−0.039– − 0.006	0.008	BMI	−0.087	−0.040– − 0.006	0.008
HT	0.125	0.145–0.445	<0.001	HT	0.126	0.148–0.449	<0.001
Time frame^a	0.307	0.031–0.046	<0.001	Time frame^a	0.307	0.031–0.046	<0.001
CRP^b	0.035	−0.059–0.217	0.261	CRP^b	0.043	−0.041–0.233	0.169

Multivariable regression analysis adjusted for age, sex, BMI, HT, Time frame, CRP and NT-proBNP
For abbreviations, see text
^aTime from symptoms to blood sampling ^bLogtransformed ^c Confidence Intervals