ARM A: | Â |
Variable dose warfarin: | Â |
 | 5.0 mg beginning the night before surgery, followed by 5.0 mg the PM of surgery, and then variable daily dose, (target INR 2.0-2.5) until day 28 ± 2 follow-up. |
ARM B: | Â |
Fondaparinux: | Â |
 | 2.5 mg daily starting 6 or more hours following surgery, but no later than 6 AM the next day, or 6-8 h after epidural catheter removal; continued until day 28 ± 2 |
ARM C: | Â |
Fixed low dose warfarin | Â |
 | 1.0 mg daily beginning 7 days preoperatively, and continued at 1.0 mg daily until day 28 ± 2 follow-up. |